Keil Julian, Kiiski Hanni, Doherty Liam, Hernandez-Urbina Victor, Vassiliou Chrystalleni, Dean Camin, Müschenich Markus, Bahmani Hamed
Department of Psychology, Christian-Albrechts-University Kiel, Germany; Ababax Health GmbH, Berlin, Germany; Department of Cognitive Science, University of Potsdam, Germany.
Ababax Health GmbH, Berlin, Germany; Department of Cognitive Science, University of Potsdam, Germany.
Brain Res. 2024 Jan 1;1822:148646. doi: 10.1016/j.brainres.2023.148646. Epub 2023 Oct 21.
Information processed in our sensory neocortical areas is transported to the hippocampus during memory encoding, and between hippocampus and neocortex during memory consolidation, and retrieval. Short bursts of high-frequency oscillations, so called sharp-wave-ripples, have been proposed as a potential mechanism for this information transfer: They can synchronize neural activity to support the formation of local neural networks to store information, and between distant cortical sites to act as a bridge to transfer information between sensory cortical areas and hippocampus. In neurodegenerative diseases like Alzheimer's Disease, different neuropathological processes impair normal neural functioning and neural synchronization as well as sharp-wave-ripples, which impairs consolidation and retrieval of information, and compromises memory. Here, we formulate a new hypothesis, that artificially inducing sharp-wave-ripples with noninvasive high-frequency visual stimulation could potentially support memory functioning, as well as target the neuropathological processes underlying neurodegenerative diseases. We also outline key challenges for empirical tests of the hypothesis.
在记忆编码过程中，我们感觉新皮层区域处理的信息会传输至海马体；在记忆巩固和检索过程中，信息则在海马体和新皮层之间传输。短阵高频振荡，即所谓的尖波涟漪，被认为是这种信息传递的一种潜在机制：它们能够使神经活动同步，以支持局部神经网络的形成来存储信息，并在远距离的皮层位点之间起到桥梁作用，在感觉皮层区域和海马体之间传递信息。在阿尔茨海默病等神经退行性疾病中，不同的神经病理过程会损害正常的神经功能、神经同步以及尖波涟漪，进而损害信息的巩固和检索，并影响记忆。在此，我们提出一个新假说，即通过非侵入性高频视觉刺激人工诱导尖波涟漪可能潜在地支持记忆功能，以及针对神经退行性疾病潜在的神经病理过程。我们还概述了对该假说进行实证检验的关键挑战。
