Ebid Heidi, Trombetta Louis D
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA.
Environ Toxicol Pharmacol. 2023 Nov;104:104302. doi: 10.1016/j.etap.2023.104302. Epub 2023 Oct 21.
Pesticides-related toxicities have long been studied. Data regarding the effects of combined exposure to environmentally relevant pesticides however remain lacking. The herbicide glyphosate and the fungicide mancozeb are extensively used in agriculture. Residues of both compounds are frequently found in food and water and therefore, environmental exposure to both pesticides is a possibility. Neurotoxicity of glyphosate, mancozeb and their combinations were investigated using mouse neuroblastoma cells. Cytotoxicity observed with the glyphosate and mancozeb combinations was higher than that observed when glyphosate was tested alone. Combinations of glyphosate followed by mancozeb increased copper, manganese, and zinc levels. Mixture of mancozeb + glyphosate increased manganese and zinc levels. Combination of mancozeb followed by glyphosate increased copper and zinc levels. Glutathione ratio was decreased as a result of combinations of glyphosate and mancozeb. The decrease in glutathione ratio was greater in the combination groups than in glyphosate alone.
与农药相关的毒性早已得到研究。然而，关于环境相关农药联合暴露影响的数据仍然缺乏。除草剂草甘膦和杀菌剂代森锰锌在农业中广泛使用。这两种化合物的残留物在食物和水中经常被发现，因此，环境中接触这两种农药是有可能的。使用小鼠神经母细胞瘤细胞研究了草甘膦、代森锰锌及其组合的神经毒性。草甘膦和代森锰锌组合观察到的细胞毒性高于单独测试草甘膦时观察到的细胞毒性。草甘膦后接代森锰锌的组合增加了铜、锰和锌的水平。代森锰锌+草甘膦混合物增加了锰和锌的水平。代森锰锌后接草甘膦的组合增加了铜和锌的水平。草甘膦和代森锰锌的组合导致谷胱甘肽比率降低。组合组中谷胱甘肽比率的降低比单独使用草甘膦时更大。
