Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY 11439, USA.
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Jamaica, NY 11439, USA.
Environ Toxicol Pharmacol. 2022 May;92:103849. doi: 10.1016/j.etap.2022.103849. Epub 2022 Mar 12.
Mancozeb is a fungicide of the ethylene bisdithiocarbamate (EBDC) class complexed to the metals manganese and zinc. Nabam is the sodium salt of the EBDC backbone. The purpose of this study was to determine if these EBDC compounds alter essential metal homeostasis and glutathione status in Sprague-Dawley rats. Our findings indicate EBDCs caused accumulation of copper in kidneys, but not liver. EBDC compounds also increased glutathione reductase activity in liver, but not kidneys, whereas only mancozeb increased glutathione peroxidase activity in the liver. Mancozeb and nabam increased total glutathione in liver, but only mancozeb increased total glutathione in the kidney. Neither mancozeb nor nabam altered glutathione ratio in either liver or kidney compared to control. Our data suggest that the EBDC backbone of mancozeb, and not the zinc or manganese moieties, is responsible for changes in glutathione status and alteration of essential metal homeostasis in rat liver and kidney.
代森锰锌是乙撑双二硫代氨基甲酸盐（EBDC）类杀菌剂，与金属锰和锌络合。代森锰是 EBDC 主链的钠盐。本研究旨在确定这些 EBDC 化合物是否会改变 Sprague-Dawley 大鼠必需金属的体内平衡和谷胱甘肽状态。我们的研究结果表明，EBDC 会导致铜在肾脏中的积累，但不会在肝脏中积累。EBDC 化合物还会增加肝脏中的谷胱甘肽还原酶活性，但不会增加肾脏中的谷胱甘肽还原酶活性，而只有代森锰会增加肝脏中的谷胱甘肽过氧化物酶活性。代森锰和代森锰钠会增加肝脏中的总谷胱甘肽，但只有代森锰会增加肾脏中的总谷胱甘肽。与对照组相比，代森锰和代森锰钠都不会改变肝脏或肾脏中谷胱甘肽的比例。我们的数据表明，代森锰中 EBDC 主链而不是锌或锰部分，是导致大鼠肝、肾中谷胱甘肽状态改变和必需金属体内平衡改变的原因。
