限时进食与阿尔茨海默病：你什么时候吃很重要。

Time-restricted feeding and Alzheimer's disease: you are when you eat.

机构信息

Department of Neurology and Center On Biological Rhythms and Sleep, Washington University School of Medicine, St Louis, MO, USA.

出版信息

Trends Mol Med. 2023 Dec;29(12):974-975. doi: 10.1016/j.molmed.2023.10.004. Epub 2023 Oct 21.

DOI:10.1016/j.molmed.2023.10.004

PMID:37872024

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10842495/

Abstract

Time-restricted feeding (TRF) has emerged as a means of synchronizing circadian rhythms, which are commonly disrupted in Alzheimer's disease (AD). Whittaker et al. demonstrate that TRF exerts protective effects in two mouse models of AD. We discuss the effects of TRF on brain health and mechanisms linking TRF to neurodegeneration.

摘要

限时喂养（TRF）已成为一种同步生物钟的方法，而生物钟在阿尔茨海默病（AD）中通常会被打乱。Whittaker 等人证明，TRF 在两种 AD 小鼠模型中发挥了保护作用。我们讨论了 TRF 对大脑健康的影响以及将 TRF 与神经退行性变联系起来的机制。