Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, IGCME, Sun Yat-Sen University, Guangzhou 510275, China.
Chem Commun (Camb). 2023 Nov 7;59(89):13348-13351. doi: 10.1039/d3cc03043a.
A TTPP probe was developed to distinguish G-quadruplexes (G4s) from other nucleic acid topologies through longer fluorescence lifetimes and higher quantum yields. In fluorescence lifetime imaging microscopy, TTPP enabled the visualization of cytoplasmic G4s in live cells, and showed the potential to detect cell apoptosis and ferroptosis by tracking cytoplasmic G4s.
一种 TTPP 探针通过更长的荧光寿命和更高的量子产率来区分四链体（G4s）和其他核酸拓扑结构。在荧光寿命成像显微镜中，TTPP 能够可视化活细胞中的细胞质 G4s，并通过跟踪细胞质 G4s 显示出检测细胞凋亡和铁死亡的潜力。
