Bertolone S J, Kent A, Patel C C
South Med J. 1986 Dec;79(12):1524-6.
The influx of Southeast Asians has expanded the differential diagnosis of microcytic, hypochromic anemia in this country. We describe four patients with hemoglobin E, all of whom had microcytic, hypochromic anemia. Hemoglobin E is benign in both the heterozygous and homozygous states. On routine hemoglobin electrophoresis at pH 8.4, hemoglobin E will migrate near the hemoglobin C and hemoglobin A2 regions. If hemoglobin E is suspected, the laboratory should be advised to do electrophoresis on citrate agar at pH 6.3.
东南亚人的涌入扩大了该国小细胞低色素性贫血的鉴别诊断范围。我们描述了4例血红蛋白E患者，他们均患有小细胞低色素性贫血。血红蛋白E在杂合子和纯合子状态下都是良性的。在pH 8.4的常规血红蛋白电泳中，血红蛋白E会迁移至血红蛋白C和血红蛋白A2区域附近。如果怀疑有血红蛋白E，应建议实验室在pH 6.3的枸橼酸盐琼脂上进行电泳。
