Handa A, Mibukura T, Aida K, Takahashi T, Hirashima K, Inoue T, Harano K, Harano T
Saitama Medical School, First Department of Internal Medicine.
Rinsho Ketsueki. 1998 Feb;39(2):146-9.
Microcytic hypochromic red blood cells (RBC) were discovered in a 31 year-old Bangladeshi man. Additional laboratory data revealed only slight elevations of LDH and transaminase activities. The patient was clinically asymptomatic and showed no signs of anemia. On this basis, along with biochemical genetic analysis of hemoglobin, a diagnosis of hemoglobinopathy (HbE) was made. HbE is common in southeast Asia with over 30% of the population affected. Most people are asymptomatic. In northern Asia, including Japan, HbE is found in only 0.001% of the population. With ther recent influx of southeast Asians to Japan, care must be taken not to overlook the diagnosis of hemoglobinopathies.
在一名31岁的孟加拉男子身上发现了小细胞低色素性红细胞（RBC）。其他实验室数据显示，乳酸脱氢酶（LDH）和转氨酶活性仅略有升高。该患者临床无症状，也无贫血迹象。基于此，结合血红蛋白的生化基因分析，诊断为血红蛋白病（HbE）。HbE在东南亚很常见，超过30%的人口受影响。大多数人无症状。在包括日本在内的亚洲北部，仅0.001%的人口中发现有HbE。随着最近东南亚人涌入日本，必须注意不要忽视血红蛋白病的诊断。
