Fava Daniela, Pepino Carlotta, Tosto Valentina, Gastaldi Roberto, Pepe Alessia, Paoloni Dalila, Strati Marina Francesca, Angelelli Alessia, Calandrino Andrea, Tedesco Caterina, Camia Tiziana, Allegri Anna Elsa Maria, Patti Giuseppa, Casalini Emilio, Bassi Marta, Calevo Maria Grazia, Napoli Flavia, Maghnie Mohamad
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy.
Pediatric Endocrinology Unit, Department of Pediatrics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
J Endocr Soc. 2023 Aug 3;7(9):bvad094. doi: 10.1210/jendso/bvad094. eCollection 2023 Aug 2.
Since the COVID-19 outbreak, the number of girls with suspected precocious puberty has increased.
To compare the incidence of idiopathic central precocious puberty (ICPP) during COVID-19 with that of the previous 4 years.
Anthropometric, biochemical, and radiological parameters were collected between January 2016 and June 2021 from 133 girls who met the Rapidly Progressive ICPP criteria (RP-ICPP).
We found a higher incidence of RP-ICPP between March 2020 and June 2021 (group 2) compared with January 2016 through March 2020 (group 1) (53.5% vs 41.1%); 2021 showed the highest annual incidence ( < .05). Group 1 and group 2 differed in age at diagnosis (7.96 ± 0.71 vs 7.61 ± 0.94; < .05), mean Tanner stage (2.86 ± 0.51 vs 2.64 ± 0; < .05), and in the time between the appearance of thelarche and diagnosis (0.93 ± 0.75 vs 0.71 ± 0.62 years, < .05). There was an increase in the number of girls aged <8 years in group 2 and a significantly higher number of girls aged >8 years was found in group 1 (42 in group 1 vs 20 in group 2, < 0.05). Overall body mass index SD score showed higher values in group 2 (1.01 ± 1.23 vs 0.69 ± 1.15; = .18), which spent an average of 1.94 ± 1.81 hours per day using electronic devices; 88.5% of this group stopped any physical activity.
A spike in new diagnoses of idiopathic (1.79-fold higher) and RP-CPP coincided with the COVID-19 pandemic. The incidence of RP-ICPP was 1.3-fold higher during COVID-19 with a trend toward an increase in body mass index SD score. The expanding use of digital devices and the reduction of daily physical activity represent possible risk factors.
自新冠疫情爆发以来，疑似性早熟的女孩数量有所增加。
比较新冠疫情期间特发性中枢性性早熟（ICPP）的发病率与前4年的发病率。
收集了2016年1月至2021年6月期间133名符合快速进展性ICPP标准（RP-ICPP）的女孩的人体测量、生化和放射学参数。
我们发现，与2016年1月至2020年3月（第1组）相比，2020年3月至2021年6月（第2组）的RP-ICPP发病率更高（53.5%对41.1%）；2021年的年发病率最高（P<0.05）。第1组和第2组在诊断年龄（7.96±0.71对7.61±0.94；P<0.05）、平均坦纳分期（2.86±0.51对2.64±0；P<0.05）以及乳房初现与诊断之间的时间（0.93±0.75对0.71±0.62年，P<0.05）方面存在差异。第2组中8岁以下女孩的数量增加，第1组中8岁以上女孩的数量显著更多（第1组42名对第2组20名，P<0.05）。总体体重指数标准差评分在第2组中显示出更高的值（1.01±1.23对0.69±1.15；P=0.18），该组平均每天使用电子设备1.94±1.81小时；该组88.5%的女孩停止了任何体育活动。
特发性（高1.79倍）和RP-CPP新诊断病例数的激增与新冠疫情同时发生。新冠疫情期间RP-ICPP的发病率高1.3倍，且体重指数标准差评分有增加趋势。数字设备使用的增加和日常体育活动的减少是可能的风险因素。
