Liu Yi, Cao Juan, Zhang Mei, Zhang Zenghui, Xia Chengcai, Guo Guili, Wang Fugang
Pharmacy College, Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
Department of Biochemistry and Molecule Biology, School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China.
J Org Chem. 2023 Nov 3;88(21):15311-15317. doi: 10.1021/acs.joc.3c01815. Epub 2023 Oct 24.
A route for cycloaddition reaction of alkenes and -butyl nitrite to synthesize Δ-isoxazolines has been developed. The overall process involves the formation of multiple chemical bonds without the use of a catalyst. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of isoxazolines.
已开发出一种通过烯烃与亚硝酸叔丁酯的环加成反应合成Δ-异恶唑啉的路线。整个过程涉及在不使用催化剂的情况下形成多个化学键。该方法具有反应条件温和、官能团耐受性好的特点，为异恶唑啉的制备提供了一种直接的方法。
