肾阻力指数、肾微血管密度与纤维化相关性的研究。
Research on the correlation between the renal resistive index, renal microvessel density, and fibrosis.
机构信息
Department of Ultrasound Medicine, China-Japan Friendship Hospital, Beijing, China.
Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
出版信息
Ren Fail. 2023;45(2):2273423. doi: 10.1080/0886022X.2023.2273423. Epub 2023 Oct 24.
BACKGROUND
This study was designed to investigate the relationship between the renal resistive index (RRI), renal microvessel density (RMD), and fibrosis in patients with chronic kidney disease (CKD).
METHODS
A total of 73 CKD patients were included in the study. Prior to kidney biopsy, we recorded the RRI of the interlobar artery and the estimated glomerular filtration rate (eGFR). Immunohistochemical analysis was performed to assess CD34 expression, and Masson staining was used to evaluate histopathological specimens for RMD and the degree of fibrosis. The percentage of the positive area (PPA) was recorded. Subsequently, we investigated the correlation between RRI, RMD, and kidney fibrosis.
RESULTS
RMD (CD34 PPA-total and CD34 PPA-peritubular capillary) showed a slight increase in early CKD stages (1-2) and gradually declined from CKD stages 2 to 5. No correlation was observed between the RRI and RMD or between the RRI and fibrosis across CKD stages 1 to 5. However, across CKD stages 2 to 5, RRI negatively correlated with CD34 PPA-glomerulus (r = -0.353, = 0.022), but no correlation was found with CD34 PPA-total, CD34 PPA-peritubular capillary, or kidney fibrosis. eGFR showed a positive correlation with RMD (CD34 PPA-total, CD34 PPA-peritubular capillary, and CD34 PPA-glomerulus) across CKD stages 2 to 5, while no correlation was found from CKD stages 1 to 5.
CONCLUSION
There was no correlation between RRI and RMD or between RRI and fibrosis across CKD stages 1 to 5 (RRI ≤ 0.7).
背景
本研究旨在探讨慢性肾脏病（CKD）患者肾阻力指数（RRI）、肾微血管密度（RMD）和纤维化之间的关系。
方法
共纳入 73 例 CKD 患者。在肾活检前，我们记录了叶间动脉的 RRI 和估算肾小球滤过率（eGFR）。采用免疫组织化学法检测 CD34 表达，Masson 染色评估 RMD 和纤维化程度的组织病理学标本。记录阳性面积的百分比（PPA）。随后，我们探讨了 RRI、RMD 和肾脏纤维化之间的相关性。
结果
RMD（CD34 PPA-总和 CD34 PPA-肾小管周毛细血管）在 CKD 早期（1-2 期）略有增加，从 CKD 2 期到 5 期逐渐下降。在 CKD 1 至 5 期，RRI 与 RMD 或 RRI 与纤维化之间均无相关性。然而，在 CKD 2 至 5 期，RRI 与 CD34 PPA-肾小球呈负相关（r=-0.353，P=0.022），但与 CD34 PPA-总、CD34 PPA-肾小管周毛细血管或肾脏纤维化无相关性。eGFR 与 RMD（CD34 PPA-总、CD34 PPA-肾小管周毛细血管和 CD34 PPA-肾小球）在 CKD 2 至 5 期呈正相关，而在 CKD 1 至 5 期无相关性。
结论
在 CKD 1 至 5 期（RRI≤0.7），RRI 与 RMD 或 RRI 与纤维化之间无相关性。
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