Fatthy Moataz, Soliman Karim M, Csongrádi Éva, Marzouk Abd El Rahman, Fathy Ahmed, Fayed Ahmed
Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.
Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Ren Fail. 2025 Dec;47(1):2462443. doi: 10.1080/0886022X.2025.2462443. Epub 2025 Feb 6.
The correlations between the intra-renal resistive index (RRI) and renal histopathology characteristics, especially in those with infected allografts, have not been sufficiently investigated in renal transplant recipients. We aimed to examine the correlation between RRI and renal allograft infection in these subjects.
One hundred nine renal allograft recipients were recruited, and RRI was evaluated for correlation with renal allograft infection. Based on laboratory and histopathological findings, 64 renal-allograft recipients were recruited for the infected group, and 45 were recruited for the non-infected group.
The causes of allograft infection were Cytomegalovirus (CMV) infection (30.3%), urinary tract infections (UTI) (18.3%), and polyomavirus 1 (BK virus) infections (10.1%). There was a statistically significant difference in RRI in those with allograft infections, with the ROC curve for detection of infection utilizing RRI demonstrated an Area Under Curve 0.634 (-value 0.015; cutoff value: 0.765; CI:0.527-0.742), with a specificity of 64.4% and a sensitivity of 68.8%.
Normal renal graft arterial resistivity index values, despite a renal allograft dysfunction, may be indicative of allograft infection, guiding clinicians' decisions regarding kidney biopsy and facilitating further biopsy interpretations.
肾移植受者肾内阻力指数（RRI）与肾组织病理学特征之间的相关性，尤其是在感染同种异体移植物的患者中，尚未得到充分研究。我们旨在研究这些受试者中RRI与肾移植感染之间的相关性。
招募了109名肾移植受者，评估RRI与肾移植感染的相关性。根据实验室和组织病理学结果，将64名肾移植受者纳入感染组，45名纳入非感染组。
同种异体移植物感染的原因包括巨细胞病毒（CMV）感染（30.3%）、尿路感染（UTI）（18.3%）和多瘤病毒1（BK病毒）感染（10.1%）。同种异体移植物感染患者的RRI存在统计学显著差异，利用RRI检测感染的ROC曲线显示曲线下面积为0.634（P值0.015；截断值：0.765；CI：0.527 - 0.742），特异性为64.4%，敏感性为68.8%。
尽管肾移植功能障碍，但正常的肾移植动脉阻力指数值可能提示同种异体移植物感染，指导临床医生关于肾活检的决策，并有助于进一步解读活检结果。
