Nagao Kenji
Health and Wellness Group, Amino Acids Department, AminoScience Division, Ajinomoto Co., Inc., Tokyo, Japan.
Curr Opin Clin Nutr Metab Care. 2024 Jan 1;27(1):40-46. doi: 10.1097/MCO.0000000000000987. Epub 2023 Oct 18.
This review underscores recent advancements in the role of protein and amino acid nutrition on cognitive health. Given the escalating prevalence of neurodegenerative disorders, particularly Alzheimer's disease, it is essential to understand nonpharmaceutical interventions that could potentially counteract their development and progression.
Emerging research indicates that moderate protein intake may offer protective benefits against dementia. Studies also emphasize the importance of considering not just the quantity, but also the quality and source of dietary protein. The role of essential amino acids in nutrition is gaining attention in the field of cognitive health. Moreover, plasma-free amino acid concentrations, particularly branched-chain amino acids, are being explored as potential biomarkers for cognitive health and Alzheimer's disease. Mechanistic studies suggest that proteins and amino acids help maintain neuronal integrity, reduce inflammation, and support muscle retention, all essential factors for cognitive health.
Recent findings emphasize the complex relationship between protein, amino acids, and cognitive health, highlighting the potential of dietary interventions in warding off neurodegenerative diseases. Given the observational nature of these findings, further interventional and longitudinal studies are needed to ascertain causality and elucidate the mechanisms involved.
本综述强调了蛋白质和氨基酸营养在认知健康方面作用的最新进展。鉴于神经退行性疾病，尤其是阿尔茨海默病的患病率不断上升，了解可能抵消其发展和进展的非药物干预措施至关重要。
新出现的研究表明，适度摄入蛋白质可能对痴呆症具有保护作用。研究还强调，不仅要考虑膳食蛋白质的数量，还要考虑其质量和来源。必需氨基酸在营养中的作用在认知健康领域正受到关注。此外，游离血浆氨基酸浓度，尤其是支链氨基酸，正被探索作为认知健康和阿尔茨海默病的潜在生物标志物。机制研究表明，蛋白质和氨基酸有助于维持神经元完整性、减轻炎症并支持肌肉保留，这些都是认知健康的重要因素。
最新发现强调了蛋白质、氨基酸与认知健康之间的复杂关系，突出了饮食干预在预防神经退行性疾病方面的潜力。鉴于这些发现的观察性质，需要进一步的干预性和纵向研究来确定因果关系并阐明其中涉及的机制。
