Hebebrand Johannes, Antel Jochen, Peters Triinu
Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Essen (AöR), University of Duisburg-Essen, Wickenburgstrasse 21, 45147, Essen, Germany.
Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Eur Child Adolesc Psychiatry. 2024 Jul;33(7):2267-2272. doi: 10.1007/s00787-023-02315-4. Epub 2023 Oct 24.
Off-label metreleptin treatment resulted in cognitive, emotional and behavioral improvements of patients with anorexia nervosa, who presented with hypoleptinemia. We now report a case study of a 16-year-old female patient with atypical anorexia nervosa who was treated off-label with metreleptin for 11 days. She had lost 21 kg over 6 months. Her body mass index at referral for inpatient treatment was 20 kg/m, her serum leptin level was just within the normal range (2.4 ng/ml). Dosing resulted in prominent improvements of mood and weight phobia entailing a comparatively brief inpatient treatment. The observed improvements are similar to those observed in patients with AN, suggesting overlapping mechanisms with respect to clinical effects induced by elevations of absolute or relative hypoleptinemia. Randomized controlled trials are warranted for both eating disorders.
非标签使用米替普明治疗可改善神经性厌食症合并低瘦素血症患者的认知、情绪和行为。我们现在报告一例16岁非典型神经性厌食症女性患者的病例研究，该患者接受了为期11天的米替普明非标签治疗。她在6个月内体重减轻了21千克。住院治疗转诊时她的体重指数为20千克/平方米，血清瘦素水平刚好在正常范围内（2.4纳克/毫升）。给药后情绪和体重恐惧有显著改善，住院治疗时间相对较短。观察到的改善与神经性厌食症患者相似，提示在由绝对或相对低瘦素血症升高引起的临床效应方面存在重叠机制。两种饮食失调症都需要进行随机对照试验。
