Savina N P
Ter Arkh. 1986;58(9):60-4.
Patients with Hodgkin's disease, Stage I-III, underwent combined therapy (polychemotherapy according to the COPP scheme and irradiation) combined with splenectomy and levamisole immunostimulation. The circulating immune complexes (IC), serum immunoglobulins of I, A and M classes and the activity of neutrophil phagocytosis at the stages of treatment, at varying time of remission and in relapse of disease were determined. Polychemotherapy and its combination with irradiation caused a decrease in the content of circulating IC associated with a decrease in the level of immunoglobulins and an increase in relative phagocytic activity. The addition of the immunostimulator brought about better elimination of IC from the body. Immunostimulators are particularly recommended in large irradiation doses received by patients in prophylactic irradiation of zones of the accumulation of the lymph nodes. Combined therapy (with and without immunostimulator) in the presence of splenectomy produced no effect in the elimination of IC from the body in early time after treatment. A study of the IC level in the blood serum is an important factor in the evaluation of the patients' immune status, therapeutic efficacy and prognosis of disease.
患有I - III期霍奇金病的患者接受了联合治疗（根据COPP方案进行多药化疗和放疗），并结合脾切除术和左旋咪唑免疫刺激。测定了治疗阶段、不同缓解期和疾病复发时循环免疫复合物（IC）、I、A和M类血清免疫球蛋白以及中性粒细胞吞噬活性。多药化疗及其与放疗的联合导致循环IC含量降低，同时免疫球蛋白水平降低，相对吞噬活性增加。添加免疫刺激剂能更好地从体内清除IC。特别推荐在对患者进行淋巴结聚集区域预防性照射时给予大剂量放疗的情况下使用免疫刺激剂。在脾切除的情况下，联合治疗（有或没有免疫刺激剂）在治疗后早期对从体内清除IC没有效果。研究血清中的IC水平是评估患者免疫状态、治疗效果和疾病预后的重要因素。
