University of California, San Francisco (UCSF) - School of Medicine, San Francisco, CA, USA.
Medical College of Wisconsin Medical School, Milwaukee, WI, USA.
Clin Exp Dermatol. 2024 Jan 25;49(2):155-159. doi: 10.1093/ced/llad359.
Psoriasis is associated with cardiometabolic comorbidities, including obesity, diabetes, hyperlipidaemia and hypertension. Many studies that established these associations originated from primarily White and/or relatively affluent populations. To evaluate whether there is a differential risk for cardiometabolic comorbidities in racial/ethnic minorities, we performed a cross-sectional analysis comparing cardiometabolic comorbidities between those with and without psoriasis in a racially and ethnically diverse population of 56 987 low-income patients, stratified by race/ethnicity, and assessed whether race/ethnicity acts as an effect modifier for cardiometabolic comorbidities. We found that psoriasis was statistically significantly associated with obesity, diabetes, hyperlipidaemia and hypertension. The association of psoriasis with comorbidities did not differ significantly by race/ethnicity; thus, we did not find evidence of effect modification. However, our diverse, low-income population had an extremely high baseline prevalence of cardiometabolic comorbidities compared with previous populations studied. Our results suggest education and intervention regarding modifiable risk factors are particularly important among vulnerable populations.
银屑病与肥胖症、糖尿病、血脂异常和高血压等心血管代谢合并症相关。许多确立这些关联的研究源自于主要为白人且/或相对富裕的人群。为了评估在种族/民族少数群体中，心血管代谢合并症是否存在不同的风险，我们在一个由 56987 名低收入患者组成的种族和民族多样化的人群中进行了一项横断面分析，比较了有和没有银屑病的患者之间的心血管代谢合并症，按种族/民族分层，并评估种族/民族是否是心血管代谢合并症的效应修饰因子。我们发现银屑病与肥胖症、糖尿病、血脂异常和高血压显著相关。银屑病与合并症的关联在种族/民族上没有显著差异；因此，我们没有发现效应修饰的证据。然而，与之前研究的人群相比，我们多样化的低收入人群的心血管代谢合并症的基线患病率极高。我们的研究结果表明，在弱势群体中，针对可改变的风险因素进行教育和干预尤其重要。
