1Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, México.
2Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México.
Pol J Microbiol. 2023 Dec 16;72(4):347-354. doi: 10.33073/pjm-2023-037. eCollection 2023 Dec 1.
Enteroaggregative (EAEC) strains have been linked to several outbreaks of severe diarrhea around the world, and this bacterium is now commonly resistant to antibiotics. As part of the pathophysiology of EAEC, the characteristic pattern of adherence looks like stacked bricks on the intestinal epithelium. This phenotype depends on an aggregative adhesion plasmid (pAA), which codes for a regulatory protein named AggR. The AggR protein is a master regulator that transcriptionally actives the main virulence genes in this pathotype, such as those that encode the aggregative adhesion fimbriae, dispersin and its secretion apparatus, Aar regulatory protein, and type VI secretion system. Several reports have shown that AggR positively affects most EAEC virulence genes, functioning as a classic transcriptional activator in the promoter region of these genes, interacting with the RNA polymerase. This minireview article integrates the information about virulence determinants of EAEC controlled by the AggR regulator.
肠聚集性 (EAEC) 菌株与世界各地的几起严重腹泻爆发有关，这种细菌现在通常对抗生素具有耐药性。在 EAEC 的病理生理学中，特征性的粘附模式看起来像肠道上皮上堆叠的砖块。这种表型取决于聚集粘附质粒 (pAA)，该质粒编码一种名为 AggR 的调节蛋白。AggR 蛋白是一种主要调节因子，可转录激活该病理型的主要毒力基因，例如编码聚集粘附菌毛、分散素及其分泌装置、Aar 调节蛋白和 VI 型分泌系统的基因。有几项报告表明，AggR 积极影响大多数 EAEC 毒力基因，作为这些基因启动子区域的经典转录激活因子，与 RNA 聚合酶相互作用。这篇综述文章整合了 AggR 调节剂控制的 EAEC 毒力决定因素的信息。
