Sydney Medical School, the University of Sydney, Sydney, NSW.
Blacktown Hospital, Blacktown, NSW.
Med J Aust. 2023 Nov 20;219(10):475-481. doi: 10.5694/mja2.52132. Epub 2023 Oct 24.
To examine the relationship between vitamin C status and demographic factors in New South Wales on the basis of serum vitamin C test results undertaken at the central pathology laboratory in Sydney, and to assess associations with age, gender, social disadvantage, and geographic remoteness.
DESIGN, SETTING: Retrospective observational study; analysis of vitamin C test results undertaken at the Royal Prince Alfred Hospital, 1 January 2017 - 31 December 2021.
Vitamin C status (normal, serum concentration ≥ 40 μmol/L; hypovitaminosis C, 12-39 μmol/L; significant deficiency, < 12 μmol/L); associations of vitamin C status with year of testing, age, gender, socio-economic status (Index of Relative Socio-Economic Advantage and Disadvantage quintile), and geographic remoteness (Australian Statistical Geography Standard); rate of hypovitaminosis C or significant deficiency test results (relative to findings of normal levels; per 100 000 estimated resident population) by Statistical Area 3.
Of 17 507 vitamin C tests undertaken during 2017-2021, 4573 were excluded (multiple tests for individuals); of 12 934 included results, 6654 were for women (51.5%), 9402 for people living in major cities (73.5%), and 81 for people in remote or very remote areas (0.6%). In multivariable multinomial regression analyses, significant deficiency (relative to normal test results) was more likely for men than women (adjusted odds ratio [aOR], 1.39; 95% confidence interval [CI], 1.27-1.52); the likelihood of hypovitaminosis C (IRSAD quintile 1 v 5, aOR, 1.35; 95% CI, 1.19-1.53) or significant deficiency (aOR, 2.07; 95% CI, 1.79-2.40) generally increased with postcode-level socio-economic disadvantage. Several of the population areas with the highest low vitamin C rates were areas of greatest disadvantage in NSW.
The prevalence of vitamin C deficiency among older people and people living in areas of socio-economic disadvantage indicates that population assessment of vitamin C levels would be appropriate.
根据在悉尼中心病理实验室进行的血清维生素 C 检测结果，研究新南威尔士州维生素 C 状况与人口统计学因素之间的关系，并评估其与年龄、性别、社会劣势和地理偏远程度的相关性。
设计、地点：回顾性观察研究；对 2017 年 1 月 1 日至 2021 年 12 月 31 日在皇家阿尔弗雷德王子医院进行的维生素 C 检测结果进行分析。
维生素 C 状态（正常，血清浓度≥40μmol/L；维生素 C 不足，12-39μmol/L；严重缺乏，<12μmol/L）；维生素 C 状态与检测年份、年龄、性别、社会经济地位（相对社会经济优势和劣势五分位数指数）和地理偏远程度（澳大利亚统计地理标准）的相关性；按统计区域 3 计算维生素 C 不足或严重缺乏检测结果的比例（相对于正常水平的发现；每 10 万估计常住人口）。
在 2017 年至 2021 年期间进行的 17507 项维生素 C 检测中，有 4573 项被排除（个人多次检测）；在所纳入的 12934 项结果中，有 6654 项是女性（51.5%），9402 项是居住在主要城市的人（73.5%），81 项是居住在偏远或非常偏远地区的人（0.6%）。在多变量多项回归分析中，与女性相比，男性更有可能出现严重缺乏（与正常检测结果相比）（校正优势比[aOR]，1.39；95%置信区间[CI]，1.27-1.52）；维生素 C 不足（IRSAD 五分位数 1 比 5，aOR，1.35；95%CI，1.19-1.53）或严重缺乏（aOR，2.07；95%CI，1.79-2.40）的可能性通常随着邮政编码级别的社会经济劣势而增加。新南威尔士州维生素 C 含量较低的一些人群地区是社会经济劣势最大的地区。
老年人和生活在社会经济劣势地区人群的维生素 C 缺乏症患病率表明，对人群的维生素 C 水平进行评估是合适的。
