矽肺与类风湿关节炎之间的关系。
Relationship between silicosis and rheumatoid arthritis.
作者信息
Sluis-Cremer G K, Hessel P A, Hnizdo E, Churchill A R
出版信息
Thorax. 1986 Aug;41(8):596-601. doi: 10.1136/thx.41.8.596.
The relationship between rheumatoid arthritis and silicosis was studied by means of a case-control study in South African gold miners. One hundred and fifty seven miners with rheumatoid arthritis classified as "definite" (91) or "probable" (66) were individually matched by year of birth with miners who had no evidence of rheumatoid arthritis. Unmatched analysis of the case-control status for "probable" and "definite" cases yielded an odds ratio of 2.84 (p = 0.0001). Separate analyses yielded an odds ratio of 3.79 (p = 0.0006) for "definite" cases, a non-significant odds ratio for "probable" cases, and an odds ratio of 5.00 (p = 0.0003) for the presence of rheumatoid factor. These results could not be explained on the basis of cumulative dust exposure or intensity of exposure. The rate of progression of silicosis in both the "definite" and the "probable" groups was greater than for the control patients with silicosis, as was the probability of silicosis presenting at the start with larger nodules (type r).
通过对南非金矿工人进行病例对照研究，探讨了类风湿性关节炎与矽肺之间的关系。157名被归类为“确诊”（91例）或“疑似”（66例）类风湿性关节炎的矿工，按出生年份与无类风湿性关节炎证据的矿工进行个体匹配。对“疑似”和“确诊”病例的病例对照状态进行非匹配分析，得出优势比为2.84（p = 0.0001）。单独分析得出，“确诊”病例的优势比为3.79（p = 0.0006），“疑似”病例的优势比无统计学意义，类风湿因子阳性的优势比为5.00（p = 0.0003）。这些结果无法用累积粉尘暴露或暴露强度来解释。“确诊”组和“疑似”组矽肺的进展速度均高于矽肺对照患者，矽肺开始时出现较大结节（r型）的概率也更高。
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