空气污染、氧化应激与自身免疫性疾病的加重
Air pollution, oxidative stress, and exacerbation of autoimmune diseases.
作者信息
Gawda Anna, Majka Grzegorz, Nowak Bernadeta, Marcinkiewicz Janusz
机构信息
Chair of Immunology, Jagiellonian University, Collegium Medicum, Krakow, Poland.
出版信息
Cent Eur J Immunol. 2017;42(3):305-312. doi: 10.5114/ceji.2017.70975. Epub 2017 Oct 30.
Abstract
A number of epidemiological studies have shown a strong association between exposure to ambient airborne particulate matter (PM 2.5, PM < 1.0) and lung or cardiovascular diseases characterised by high mortality and morbidity. However, much less is known about the role of air pollution in the pathogenesis of autoimmune diseases, which constitutes a significant problem in modern society. This paper summarises the state of current research regarding the influence of PM on the development and/or progression of autoimmune diseases. A brief review of the great body of research concerning pathogenesis of autoimmune disorders is presented. Then, the scope of our review is narrowed to the research related to the impact of particulate matter on oxidative and nitrosative stress, as well as exacerbation of chronic inflammation, because they can contribute to the development of autoimmune diseases. Moreover, we discuss the impact of various components of PM (metal, organic compounds) on PM toxicity and the ability to generate oxidants.
摘要
多项流行病学研究表明，暴露于环境空气中的颗粒物（PM 2.5、PM < 1.0）与以高死亡率和高发病率为特征的肺部或心血管疾病之间存在密切关联。然而，关于空气污染在自身免疫性疾病发病机制中的作用，人们了解得要少得多，而自身免疫性疾病是现代社会中的一个重大问题。本文总结了目前关于PM对自身免疫性疾病发展和/或进展影响的研究现状。简要回顾了关于自身免疫性疾病发病机制的大量研究。然后，我们的综述范围缩小到与颗粒物对氧化应激和亚硝化应激的影响以及慢性炎症加剧相关的研究，因为它们可能促成自身免疫性疾病的发展。此外，我们还讨论了PM的各种成分（金属、有机化合物）对PM毒性和产生氧化剂能力的影响。
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