Department of Mathematics, Duke University, Durham, NC, USA.
Department of Biology, Duke University, Durham, NC, USA.
J Biol Dyn. 2023 Dec;17(1):2269986. doi: 10.1080/17513758.2023.2269986. Epub 2023 Oct 24.
In volume transmission (or neuromodulation) neurons do not make one-to-one connections to other neurons, but instead simply release neurotransmitter into the extracellular space from numerous varicosities. Many well-known neurotransmitters including serotonin (5HT), dopamine (DA), histamine (HA), Gamma-Aminobutyric Acid (GABA) and acetylcholine (ACh) participate in volume transmission. Typically, the cell bodies are in one volume and the axons project to a distant volume in the brain releasing the neurotransmitter there. We introduce volume transmission and describe mathematically two natural homeostatic mechanisms. In some brain regions several neurotransmitters in the extracellular space affect each other's release. We investigate the dynamics created by this comodulation in two different cases: serotonin and histamine; and the comodulation of 4 neurotransmitters in the striatum and we compare to experimental data. This kind of comodulation poses new dynamical questions as well as the question of how these biochemical networks influence the electrophysiological networks in the brain.
在容积传递（或神经调节）中，神经元不会与其他神经元进行一对一的连接，而是从众多的膨体中将神经递质简单地释放到细胞外间隙中。许多著名的神经递质，包括血清素（5HT）、多巴胺（DA）、组胺（HA）、γ-氨基丁酸（GABA）和乙酰胆碱（ACh），都参与了容积传递。通常，细胞体位于一个容积中，轴突投射到大脑中的一个遥远容积，在那里释放神经递质。我们介绍了容积传递，并从数学上描述了两种自然的体内平衡机制。在一些脑区，细胞外间隙中的几种神经递质会相互影响彼此的释放。我们研究了这两种不同情况下的共调制所产生的动力学：血清素和组胺；以及纹状体中 4 种神经递质的共调制，并与实验数据进行了比较。这种共调制不仅提出了新的动力学问题，还提出了这些生化网络如何影响大脑中的电生理网络的问题。
