Das Aranya, Ajarul Sk, Debnath Sudipto, Hota Poulami, Maiti Dilip K
Department of Chemistry, University of Calcutta, 92, A. P. C. Road, Kolkata 700009, India.
Government General Degree College at Salboni, Bhimpur, Paschim Medinipur 721516, India.
J Org Chem. 2023 Nov 3;88(21):15073-15084. doi: 10.1021/acs.joc.3c01525. Epub 2023 Oct 24.
An unprecedented -TsOH and MsOH-catalyzed construction of valuable isoindolo/pyrido/pyrrolo-quinolinediones and isoindolo-indolones is demonstrated through annulation reactions of cyclic anhydrides or -formylbenzoates with -alkynylanilines. The metal-free Bro̷nsted acid-mediated new [5+1] and [4+1] fused-cyclization is an operationally simple, highly regioselective, atom economical, high yielding, sustainable, and catalytically efficient approach.
通过环状酸酐或甲酰基苯甲酸酯与炔基苯胺的环化反应，展示了一种前所未有的由对甲苯磺酸（TsOH）和甲磺酸（MsOH）催化构建有价值的异吲哚并/吡啶并/吡咯并喹啉二酮和异吲哚并吲哚酮的方法。这种无金属的布朗斯特酸介导的新型[5+1]和[4+1]稠环化反应是一种操作简单、区域选择性高、原子经济性好、产率高、可持续且催化效率高的方法。
