过渡金属催化的 C-H 活化/环化方法构建异吲哚并[2,1-b]异喹啉-5(7H)-酮。
Transition Metal-Catalyzed C-H Activation/Annulation Approaches to Isoindolo[2,1-b]isoquinolin-5(7H)-ones.
机构信息
College of Science, Nanjing Forestry University, Nanjing, 210037, China.
Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, Jiangsu, China.
出版信息
Chem Rec. 2023 Mar;23(3):e202200255. doi: 10.1002/tcr.202200255. Epub 2023 Jan 16.
The isoindolo[2,1-b]isoquinolin-5(7H)-one scaffold is widely present in lots of bioactive natural products. Diverse types of strategies have been developed to construct this scaffold. Recently, transition metal-catalyzed C-H activation/annulation is emerging as a powerful and straightforward method to construct diverse polyheterocycles with high atom- and step-economy. It also has been employed for the synthesis of the isoindolo[2,1-b]isoquinolin-5(7H)-one scaffold. This review provides an introduction to recent advances for the preparation of isoindolo[2,1-b]isoquinolin-5(7H)-ones by using transition metal-catalyzed C-H activation/annulation. It will help researchers to find hidden opportunities and accelerate the discovery of novel transformations based on C-H activation/annulation.
异吲哚并[2,1-b]异喹啉-5(7H)-酮骨架广泛存在于许多生物活性天然产物中。已经开发出多种策略来构建这个骨架。最近，过渡金属催化的 C-H 活化/环化反应作为一种构建具有高原子经济性和步骤经济性的各种多杂环的有力且直接的方法而崭露头角。它也被用于合成异吲哚并[2,1-b]异喹啉-5(7H)-酮骨架。本综述介绍了利用过渡金属催化的 C-H 活化/环化反应来制备异吲哚并[2,1-b]异喹啉-5(7H)-酮的最新进展。这将有助于研究人员发现潜在的机会，并加速基于 C-H 活化/环化的新转化的发现。
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