芬兰脊髓灰质炎暴发：无明显的HLA关联。

Outbreak of poliomyelitis in Finland: no distinct HLA association.

作者信息

Kinnunen E, Hovi T, Koskimies S

出版信息

Tissue Antigens. 1986 Sep;28(3):190-1. doi: 10.1111/j.1399-0039.1986.tb00480.x.

DOI:10.1111/j.1399-0039.1986.tb00480.x

Abstract

In 1984 to 1985 an outbreak of poliomyelitis was found after a 20-year free period in Finland. The 10 patients with central nervous system disease were studied for HLA antigens. Additionally, two families with two and four affected siblings from the previous outbreak were analysed. The affection of the central nervous system seems not to depend on HLA-associated genetic factors.

摘要

1984年至1985年期间，芬兰在经历了20年无脊髓灰质炎疫情后出现了一次疫情爆发。对10例患有中枢神经系统疾病的患者进行了HLA抗原研究。此外，还分析了来自上一次疫情爆发的两个家庭，其中一个家庭有2名患病兄弟姐妹，另一个家庭有4名患病兄弟姐妹。中枢神经系统的病变似乎并不取决于与HLA相关的遗传因素。