6-巯基嘌呤处理大鼠比目鱼肌的肌肉萎缩与组织病理学

Muscle atrophy and histopathology of the soleus in 6-mercaptopurine-treated rats.

作者信息

Jaweed M M, Alleva F R, Herbison G J, Ditunno J F, Balazs T

出版信息

Toxicol Ind Health. 1986 Sep;2(2):31-40. doi: 10.1177/074823378600200204.

DOI:10.1177/074823378600200204

Abstract

In this study, male and female Sprague-Dawley rats were treated neonatally with 6-MP-treatment (2 mg/kg s/c, between 2 and 22 days after birth) and evaluated at six months of age. Compared to the normal controls, the 6-MP-treated male and female rats showed similar sciatic nerve conduction to the soleus. However, there was a significant muscle atrophy (57-60%, P less than 0.01) and a decrease in areas of the type I (42-54%, P less than 0.05) and type II (41-71%, P less than 0.01) muscle fibers. The number of type II fibers declined significantly (7.4-14.8%, P less than 0.05). It is proposed that the soleus muscle atrophy and histopathology in 6-MP-treated rats is unrelated to nerve conduction defects and may be related to growth inhibition caused by an interference of the drug during normal differentiation of muscle fibers.

摘要

在本研究中，对新生的雄性和雌性斯普拉格-道利大鼠在出生后2至22天进行6-巯基嘌呤（6-MP）处理（皮下注射，剂量为2 mg/kg），并在6个月龄时进行评估。与正常对照组相比，经6-MP处理的雄性和雌性大鼠比目鱼肌的坐骨神经传导情况相似。然而，出现了明显的肌肉萎缩（57 - 60%，P < 0.01），并且I型（42 - 54%，P < 0.05）和II型（41 - 71%，P < 0.01）肌纤维面积减少。II型纤维数量显著下降（7.4 - 14.8%，P < 0.05）。据推测，经6-MP处理的大鼠比目鱼肌萎缩和组织病理学变化与神经传导缺陷无关，可能与药物在肌纤维正常分化过程中产生干扰导致的生长抑制有关。