Shaoxing Key Laboratory of Reproductive Health, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, China.
Neonatal Intensive Care Unit, Shaoxing Maternity and Child Health Care Hospital, Shaoxing, Zhejiang, China.
Front Endocrinol (Lausanne). 2023 Oct 9;14:1288347. doi: 10.3389/fendo.2023.1288347. eCollection 2023.
Prematurity is due to a number of factors, especially genetics. This study was designed to evaluate the impact of a pharmacist-led patient-centered medication therapy management trial on iron deficiency and medication adherence among premature infants receiving iron supplementation at a tertiary hospital in Shaoxing, China.
In this randomised controlled trial, eighty-one premature infants, with or without genetic factors, born at 26 to 30 weeks and 6 days gestational age, will be recruited and randomised to an intervention group or a control group. The intervention group will receive a pharmacist-driven discharge counseling on iron supplements from recruitment, until 12 months. The control group will receive care as usual. The main outcomes were haemoglobin (g/L), serum iron (μg/L), medication adherence estimation and differentiation scale, the satisfaction with information about medicines scale, beliefs about medicines questionnaire and the Bayley scales for infant development.
A total of 81 patients were enrolled in the study. After intervention, results for the haemoglobin and serum iron differed significantly between the control group and the intervention group (101.36 vs. 113.55, P < 0.0001 and 51.13 vs. 101.36, P = 0.004). Additionally, there was a substantial difference between the intervention group and the control group in terms of patient medication adherence estimation and differentiation scale (27 vs. 34, P = 0.0002). the intervention group had better mental development index and psychomotor development index, compared with the control group (91.03 vs. 87.29, P = 0.035 and 95.05 vs. 90.00, P = 0.022).
In premature infants with iron deficiency, our pharmacist-led team significantly improved clinical outcomes and medication adherence.
早产是由多种因素引起的，尤其是遗传因素。本研究旨在评估药师主导的以患者为中心的药物治疗管理试验对在中国绍兴一家三级医院接受铁补充剂的早产儿缺铁和药物依从性的影响。
在这项随机对照试验中，将招募 81 名患有或不患有遗传因素的 26 至 30 周 6 天胎龄的早产儿，并将其随机分为干预组或对照组。干预组将从招募开始接受药师主导的铁补充剂出院咨询，直到 12 个月。对照组将接受常规护理。主要结局是血红蛋白（g/L）、血清铁（μg/L）、药物依从性评估和分化量表、对药物信息的满意度量表、药物信念问卷和贝利婴儿发育量表。
共有 81 名患者入组研究。干预后，对照组和干预组的血红蛋白和血清铁差异有统计学意义（101.36 对 113.55，P<0.0001 和 51.13 对 101.36，P=0.004）。此外，干预组和对照组在患者药物依从性评估和分化量表方面也存在显著差异（27 对 34，P=0.0002）。与对照组相比，干预组的精神发育指数和运动发育指数更高（91.03 对 87.29，P=0.035 和 95.05 对 90.00，P=0.022）。
在缺铁的早产儿中，我们的药师主导团队显著改善了临床结局和药物依从性。
