Country Renal Research Institution of Beijing University of Chinese Medicine, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2023 Oct 9;14:1244705. doi: 10.3389/fendo.2023.1244705. eCollection 2023.
Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) and the main cause of excess mortality in patients with type 2 DM. The pathogenesis and progression of DN are closely associated with disorders of glucose and lipid metabolism. As a member of the sirtuin family, SIRT6 has deacetylation, defatty-acylation, and adenosine diphosphate-ribosylation enzyme activities as well as anti-aging and anticancer activities. SIRT6 plays an important role in glucose and lipid metabolism and signaling, especially in DN. SIRT6 improves glucose and lipid metabolism by controlling glycolysis and gluconeogenesis, affecting insulin secretion and transmission and regulating lipid decomposition, transport, and synthesis. Targeting SIRT6 may provide a new therapeutic strategy for DN by improving glucose and lipid metabolism. This review elaborates on the important role of SIRT6 in glucose and lipid metabolism, discusses the potential of SIRT6 as a therapeutic target to improve glucose and lipid metabolism and alleviate DN occurrence and progression of DN, and describes the prospects for future research.
糖尿病肾病（DN）是糖尿病（DM）的一种并发症，也是 2 型糖尿病患者死亡的主要原因。DN 的发病机制和进展与糖、脂代谢紊乱密切相关。SIRT6 作为 sirtuin 家族的一员，具有去乙酰化、去脂肪酰化和二磷酸腺苷核糖基化酶活性以及抗衰老和抗癌活性。SIRT6 在糖和脂代谢及信号转导中发挥重要作用，特别是在 DN 中。SIRT6 通过控制糖酵解和糖异生、影响胰岛素分泌和传递以及调节脂分解、转运和合成来改善糖和脂代谢。针对 SIRT6 可能为改善糖脂代谢提供一种治疗 DN 的新策略。本文详细阐述了 SIRT6 在糖脂代谢中的重要作用，探讨了 SIRT6 作为治疗靶点改善糖脂代谢、减轻 DN 发生和进展的潜力，并描述了未来研究的前景。
