Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4921, USA.
Cells. 2022 Oct 14;11(20):3236. doi: 10.3390/cells11203236.
Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis. This review highlights lipotoxicity pathways in the podocyte and proximal tubule cell, which are arguably the two most critical sites in the nephron for DKD. The discussion focuses on membrane transporters and lipid droplets, which represent potential therapeutic targets, as well as current and developing pharmacologic approaches to reduce renal lipotoxicity.
脂毒性是糖尿病和非酒精性脂肪肝的基本病理生理机制，目前在糖尿病肾病（DKD）发病机制中也越来越受到重视。本文重点介绍了足细胞和近端肾小管细胞中的脂毒性途径，这两个细胞可以说是肾病中最重要的两个部位。本文讨论了膜转运蛋白和脂滴，它们是潜在的治疗靶点，以及目前和正在开发的降低肾脏脂毒性的药物治疗方法。
