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有症状的不可逆性牙髓炎患者龈沟液中神经激肽A和P物质水平：一项系统评价和Meta分析

Gingival Crevicular Fluid Levels of Neurokinin A and Substance P in Patients with Symptomatic Irreversible Pulpitis: A Systematic Review and Meta-Analysis.

作者信息

Abraham Dax, Singh Arundeep, Goyal Anjana

机构信息

Department of Conservative Dentistry and Endodontics, School of Dental Sciences, MRIIRS, Faridabad, Haryana, India.

Department of Biochemistry, School of Dental Sciences, MRIIRS, Faridabad, Haryana, India.

出版信息

J Int Soc Prev Community Dent. 2023 Aug 30;13(4):307-317. doi: 10.4103/jispcd.JISPCD_55_23. eCollection 2023 Jul-Aug.

DOI:10.4103/jispcd.JISPCD_55_23
PMID:37876583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10593367/
Abstract

AIMS AND OBJECTIVES

The levels of neuropeptides neurokinin A (NKA) and substance P (SP) in the gingival crevicular fluid of patients with symptomatic irreversible pulpitis (SIP) were evaluated using a comprehensive review and meta-analysis.

MATERIALS AND METHODS

The data bases of Pubmed, Scopus, EBSCOhost, Science Direct, Proquest and Cochrane library databases were thoroughly searched. The quality of the study was evaluated using the Joanna Briggs Criteria. Twenty four studies were listed following a thorough search of full texts, abstracts, and removal of duplicates. Only two of these papers were eligible for inclusion in the meta-analysis. Since the results obtained were in mean and standard deviation, the levels of neuropeptides in the test and control groups were examined using the meta-analysis.

RESULTS

When compared with healthy teeth, NKA was not significantly elevated in GCF of individuals with SIP ( = 0.06; odd ratio = 1.34 [-0.05 to 2.74] at 95% confidence interval [CI]). Additionally, there was no evidence of an association between SP and SIP ( = 0.08; odds ratio = 0.84 [-0.10 to 1.77] at 95% CI).

CONCLUSION

This systematic research demonstrated that in individuals with SIP, NKA, and SP are not substantially linked. However, the lack of study in this area makes it evident that additional research is needed, particularly in relation to pulpal disorders and NKA.

摘要

目的与目标

采用全面综述和荟萃分析的方法，评估有症状不可逆性牙髓炎（SIP）患者龈沟液中神经肽神经激肽A（NKA）和P物质（SP）的水平。

材料与方法

全面检索了PubMed、Scopus、EBSCOhost、ScienceDirect、ProQuest和Cochrane图书馆数据库。使用乔安娜·布里格斯标准评估研究质量。在对全文、摘要进行全面检索并去除重复项后，列出了24项研究。其中只有两篇论文符合纳入荟萃分析的条件。由于获得的结果是均值和标准差，因此使用荟萃分析检查测试组和对照组中神经肽的水平。

结果

与健康牙齿相比，SIP患者龈沟液中的NKA没有显著升高（P = 0.06；优势比 = 1.34 [-0.05至2.74]，95%置信区间[CI]）。此外，没有证据表明SP与SIP之间存在关联（P = 0.08；优势比 = 0.84 [-0.10至1.77]，95% CI）。

结论

这项系统研究表明，在SIP患者中，NKA和SP没有实质性关联。然而，该领域研究的缺乏表明需要进行更多研究，特别是关于牙髓疾病和NKA的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/f512bc90a7c1/JISPCD-13-307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/d7b16b09cd56/JISPCD-13-307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/c69c6c8fc83a/JISPCD-13-307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/9dce645623ee/JISPCD-13-307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/c93165864756/JISPCD-13-307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/f512bc90a7c1/JISPCD-13-307-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/d7b16b09cd56/JISPCD-13-307-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/c69c6c8fc83a/JISPCD-13-307-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/9dce645623ee/JISPCD-13-307-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/c93165864756/JISPCD-13-307-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c2a/10593367/f512bc90a7c1/JISPCD-13-307-g005.jpg

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本文引用的文献

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Unlocking the Diagnostic Potential of Saliva: A Comprehensive Review of Infrared Spectroscopy and Its Applications in Salivary Analysis.挖掘唾液的诊断潜力：红外光谱及其在唾液分析中的应用综述
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