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耳鼻咽喉头颈结核的发病率、诊断与治疗:一项前瞻性临床研究

Incidence, Diagnosis and Treatment of Otorhinolaryngological, Head and Neck Tuberculosis: A Prospective Clinical Study.

作者信息

Chhabra Biban, Vyas Pratibha, Gupta Priyanshi, Sharma Prateek, Sharma Kanika

机构信息

Department of Otorhinolaryngology and Head and Neck Surgery, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

出版信息

Int Arch Otorhinolaryngol. 2023 Mar 24;27(4):e630-e635. doi: 10.1055/s-0043-1761173. eCollection 2023 Oct.

Abstract

Tuberculosis is a disease of diversified presentation. It affects almost all organs in the body, and otorhinolaryngological, head and neck involvement is not an exception.  To increase awareness about the different clinical presentations of otorhinolaryngological, head and neck tuberculosis, the techniques employed to diagnose it, and to assess the response to the treatment.  We conducted a prospective study of 114 patients who presented primarily with otorhinolaryngological, head and neck tuberculosis. Routine blood investigations, chest radiographs, the tuberculin test, and sputum examination for the presence of acid-fast bacilli were performed in all cases. Site-specific investigations were performed in relevant cases only. The patients were treated according to the antitubercular treatment (ATT) regimen recommended by the Indian Ministry of Health and Family Welfare's National Tuberculosis Elimination Program (NTEP), and they were followed up clinically two and six months after starting the ATT.  Tubercular cervical lymphadenopathy was the most common clinical presentation (85.96%), followed by deep neck abscess (5.27%). Fine-needle aspiration cytology proved to be a reliable tool for the diagnosis of tubercular lymphadenopathy. Improvement at the end of 2 and 6 months of the ATT was observed in 90.35% and 96.50% of the cases respectively.  The diagnosis of otorhinolaryngological, head and neck tuberculosis requires a high index of clinical suspicion, and the ATT proved to be very effective in reducing the severity of the disease.

摘要

结核病是一种临床表现多样的疾病。它几乎会影响身体的所有器官,耳鼻咽喉科、头颈部受累也不例外。为了提高对耳鼻咽喉科、头颈部结核病不同临床表现、诊断方法以及治疗反应评估的认识,我们对114例主要表现为耳鼻咽喉科、头颈部结核病的患者进行了一项前瞻性研究。所有病例均进行了常规血液检查、胸部X光片、结核菌素试验以及痰涂片找抗酸杆菌检查。仅在相关病例中进行了特定部位的检查。患者按照印度卫生与家庭福利部国家结核病消除计划(NTEP)推荐的抗结核治疗(ATT)方案进行治疗,并在开始ATT治疗后的2个月和6个月进行临床随访。结核性颈淋巴结病是最常见的临床表现(85.96%),其次是颈部深部脓肿(5.27%)。细针穿刺细胞学检查被证明是诊断结核性淋巴结病的可靠工具。分别在90.35%和96.50%的病例中观察到ATT治疗2个月和6个月后病情有所改善。耳鼻咽喉科、头颈部结核病的诊断需要高度的临床怀疑,而ATT被证明在减轻疾病严重程度方面非常有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7160/10593515/be9dd595e744/10-1055-s-0043-1761173-i211183-1.jpg

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