Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Front Cell Infect Microbiol. 2023 Oct 9;13:1253447. doi: 10.3389/fcimb.2023.1253447. eCollection 2023.
The gut microbiota is closely linked to cholesterol metabolism-related diseases such as obesity and cardiovascular diseases. However, whether gut microbiota plays a causal role in cholelithiasis remains unclear.
This study explored the causal relationship between gut microbiota and cholelithiasis. We hypothesize that the gut microbiota influences cholelithiasis development.
A two-sample Mendelian randomization method was combined with STRING analysis to test this hypothesis. Summary data on gut microbiota and cholelithiasis were obtained from the MiBioGen (n=13,266) and FinnGen R8 consortia (n=334,367), respectively.
, , and increased the risk of cholelithiasis and expressed more bile salt hydrolases. In contrast, , , and weakly expressed bile salt hydrolases and were implied to have a protective effect against cholelithiasis by Mendelian randomization analysis.
Gut microbiota causally influences cholelithiasis and may be related to bile salt hydrolases. This work improves our understanding of cholelithiasis causality to facilitate the development of treatment strategies.
肠道微生物群与胆固醇代谢相关疾病（如肥胖症和心血管疾病）密切相关。然而，肠道微生物群是否在胆石症中发挥因果作用尚不清楚。
本研究探讨了肠道微生物群与胆石症之间的因果关系。我们假设肠道微生物群影响胆石症的发展。
采用两样本 Mendelian 随机化方法结合 STRING 分析来检验这一假设。分别从 MiBioGen（n=13266）和 FinnGen R8 联盟（n=334367）中获取肠道微生物群和胆石症的汇总数据。
、 、 和 增加了胆石症的风险，并表达了更多的胆盐水解酶。相反， 、 、 和 弱表达胆盐水解酶，通过 Mendelian 随机化分析表明对胆石症具有保护作用。
肠道微生物群因果关系地影响胆石症，可能与胆盐水解酶有关。这项工作提高了我们对胆石症因果关系的理解，有助于开发治疗策略。
