Hao Yihong, Ren Jieqiong, Han Jie, Hao Dajiang
Department of Neurosurgery, The Third People's Hospital of Datong, Datong, China.
Brain Behav. 2025 Sep;15(9):e70852. doi: 10.1002/brb3.70852.
Meningiomas, the second most common intracranial tumors, account for over one-third of primary central nervous system tumors. Recent studies suggest a link between trace elements, nutrients, and tumor development. This study used Mendelian randomization (MR) to investigate causal links between trace elements, nutrients, and meningioma.
The data for trace elements and nutrients were derived from the published IEU OpenGWAS database. The genome-wide association study data for meningiomas were sourced from the Finnish database. Two-sample MR approach was leveraged to examine the causal link of seven trace elements and eight nutrients with meningioma. Inverse-variance weighted (IVW), MR-Egger test, and weighted median methods were applied to infer causal links. Sensitivity analyses were performed to examine the robustness of the results. Reverse MR (RMR) analysis was further carried out with meningiomas as the exposure factor and trace elements and nutrients as the outcome. A multivariable MR (MVMR) method was adopted to appraise the combined effects of several exposure factors on meningioma.
The two-sample MR analysis revealed that Zn (OR = 1.484, 95% CI: 1.222-1.803, p = 6.90E-05), as an exposure factor, may increase the risk of meningioma. The RMR analysis indicated no evident causal connection. According to the MVMR analysis, Zn was an independent risk factor for meningiomas (OR = 1.391, 95% CI: 0.042-0.617, p = 0.025).
Zn is an independent risk factor for meningioma, which is significant for developing prevention and management strategies for meningioma.
脑膜瘤是第二常见的颅内肿瘤，占原发性中枢神经系统肿瘤的三分之一以上。最近的研究表明微量元素、营养素与肿瘤发展之间存在联系。本研究采用孟德尔随机化（MR）方法来研究微量元素、营养素与脑膜瘤之间的因果关系。
微量元素和营养素的数据来自已发表的IEU OpenGWAS数据库。脑膜瘤的全基因组关联研究数据来自芬兰数据库。采用两样本MR方法来检验七种微量元素和八种营养素与脑膜瘤之间的因果关系。应用逆方差加权（IVW）、MR-Egger检验和加权中位数方法来推断因果关系。进行敏感性分析以检验结果的稳健性。进一步以脑膜瘤作为暴露因素，微量元素和营养素作为结果进行反向MR（RMR）分析。采用多变量MR（MVMR）方法来评估几种暴露因素对脑膜瘤的综合影响。
两样本MR分析显示，作为暴露因素的锌（OR = 1.484，95%CI：1.222 - 1.803，p = 6.90E - 05）可能增加脑膜瘤风险。RMR分析表明没有明显的因果联系。根据MVMR分析，锌是脑膜瘤的独立危险因素（OR = 1.391，95%CI：0.042 - 0.617，p = 0.025）。
锌是脑膜瘤的独立危险因素，这对于制定脑膜瘤的预防和管理策略具有重要意义。
