Lababidi Hossam, Salerno Pedro Rvo, Wass Sojin Youn, Shafiabadi Hasani Neda, Bourges-Sevenier Brendan, Al-Kindi Sadeer
Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Int J Cardiol Cardiovasc Risk Prev. 2023 Sep 23;19:200212. doi: 10.1016/j.ijcrp.2023.200212. eCollection 2023 Dec.
Premature cardiovascular disease (pCVD) definition varies in literature, with age cut-offs ranging from 50-65 years. While there is some literature available on pCVD in North America, comprehensive data on its global burden is still lacking which hinders the development of efficient strategies for early detection and prevention. In this study we aimed to investigate the global trends in pCVD related morbidity and mortality from 1990 to 2019.
The 1990-2019 Global Burden of Disease (GBD) database was utilized to examine global trends in cardiovascular disease-related total mortality, mortality rates, and Disability-Adjusted Life Years (DALYs) within individuals aged 15-49 years. The findings were further analyzed based on factors such as age, sex, and Socio-Demographic Index (SDI).
From 1990 to 2019, the number of global annual pCVD deaths increased by 25%, from 992,067 (95% UI 1,042,261 - 946,383) to 1,241,484 (95% UI 1,339,193 -1,146,252). The rate of associated mortality decreased by 13%. Metabolic conditions were the most significant risk factors for pCVD mortality. Ischemic heart disease and stroke are the leading causes of death across all age groups. pCVD mortality presented progressive widening between high and low SDI regions. Additionally, sex-specific disparities in CVD mortality were significantly greater in the premature age group as compared to all-age groups.
pCVD is an increasingly significant global cause of morbidity and mortality that disproportionately affects males and individuals living in less privileged regions. Furthermore, ischemic heart disease and stroke were identified as the main drivers of pCVD global burden.
心血管疾病过早发病（pCVD）的定义在文献中各不相同，年龄界限在50至65岁之间。虽然北美有一些关于pCVD的文献，但仍缺乏其全球负担的综合数据，这阻碍了早期检测和预防有效策略的制定。在本研究中，我们旨在调查1990年至2019年pCVD相关发病率和死亡率的全球趋势。
利用1990 - 2019年全球疾病负担（GBD）数据库，研究15至49岁个体中心血管疾病相关的总死亡率、死亡率和伤残调整生命年（DALY）的全球趋势。根据年龄、性别和社会人口指数（SDI）等因素对研究结果进行进一步分析。
1990年至2019年，全球每年pCVD死亡人数增加了25%，从992,067例（95% UI 1,042,261 - 946,383）增至1,241,484例（95% UI 1,339,193 - 1,146,252）。相关死亡率下降了13%。代谢状况是pCVD死亡的最重要危险因素。缺血性心脏病和中风是所有年龄组的主要死因。pCVD死亡率在高SDI地区和低SDI地区之间呈现出逐渐扩大的趋势。此外，与所有年龄组相比，过早年龄组中心血管疾病死亡率的性别差异更为显著。
pCVD是一个日益重要的全球发病和死亡原因，对男性和生活在较贫困地区的个体影响尤为严重。此外，缺血性心脏病和中风被确定为pCVD全球负担的主要驱动因素。
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