Li Cangtuo, Qi Qi, Li Wansong, Zhang Xuechao, Li Lei, Deng Jie, Han Quanle, Wu Shouling, Li Kangbo
Department of Vascular and Interventional Radiology, Tangshan Gongren Hospital, Tangshan, China
Hebei Medical University, Shijiazhuang, China
Balkan Med J. 2025 Jul 1;42(4):339-346. doi: 10.4274/balkanmedj.galenos.2025.2025-2-109. Epub 2025 Jun 3.
The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established.
To investigate the potential of the TyG index to predict MACCEs in a non-diabetic population.
Prospective cohort study.
This study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs.
Participants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older.
The TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes.
在无糖尿病个体中，甘油三酯与血糖（TyG）指数和主要心血管和脑血管不良事件（MACCEs）发生之间的关联尚未明确确立。
探讨TyG指数预测非糖尿病人群中MACCEs的潜力。
前瞻性队列研究。
本研究分析了88946名无糖尿病参与者的数据，这些参与者根据其TyG指数值分为四组。主要结局是MACCEs的发生，定义为心肌梗死（MI）或中风。采用多变量Cox比例风险回归模型评估TyG指数与MACCEs之间的关联。
TyG指数较高四分位数的参与者发生MACCEs的风险更大。此外，还发现TyG指数与性别之间存在显著交互作用，女性中的关联比男性更强。在TyG指数与年龄关于MI风险方面也发现了显著交互作用，表明与60岁及以上个体相比，60岁以下个体中的关联更强。
TyG指数可能是无糖尿病个体中MACCEs的有用预后标志物。
