Institute of Virology, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.
Front Immunol. 2023 Oct 9;14:1286617. doi: 10.3389/fimmu.2023.1286617. eCollection 2023.
Pioneer factors are transcription factors sharing the fascinating ability to bind to compact chromatin and thereby alter its transcriptional fate. Most pioneer factors are known for their importance during embryonic development, for instance, in inducing zygotic genome activation or cell fate decision. Some pioneer factors are actively induced or downregulated by viral infection. With this, viruses are capable to modulate different signaling pathways resulting for example in MHC-receptor up/downregulation which contributes to viral immune evasion. In this article, we review the current state of research on how different viruses (Herpesviruses, Papillomaviruses and Hepatitis B virus) use pioneer factors for their viral replication and persistence in the host, as well as for the development of viral cancer.
先驱因子是一类转录因子，它们具有令人着迷的能力，可以结合到紧凑的染色质上，从而改变其转录命运。大多数先驱因子在胚胎发育过程中非常重要，例如，在诱导合子基因组激活或细胞命运决定中。一些先驱因子会被病毒感染主动诱导或下调。因此，病毒能够调节不同的信号通路，例如 MHC 受体的上调/下调，这有助于病毒的免疫逃逸。在本文中，我们综述了不同病毒（疱疹病毒、乳头瘤病毒和乙型肝炎病毒）如何利用先驱因子进行病毒复制和在宿主中持续存在，以及如何促进病毒致癌的研究现状。
