He Zhihong, He Jie, Xie Keping
Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, China.
The South China University of Technology Comprehensive Cancer Center, Guangdong, China.
Cell Death Discov. 2023 Apr 8;9(1):118. doi: 10.1038/s41420-023-01416-y.
Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death. KLF4 is a prominent member of this family, and embryonic deletion of KLF4 leads to alterations in skin permeability and postnatal death. In addition to its important role in embryo development, it also plays a critical role in inflammation and malignancy. It has been investigated that KLF4 has a regulatory role in a variety of cancers, including lung, breast, prostate, colorectal, pancreatic, hepatocellular, ovarian, esophageal, bladder and brain cancer. However, the role of KLF4 in tumorigenesis is complex, which may link to its unique structure with both transcriptional activation and transcriptional repression domains, and to the regulation of its upstream and downstream signaling molecules. In this review, we will summarize the structural and functional aspects of KLF4, with a focus on KLF4 as a clinical biomarker and therapeutic target in different types of tumors.
Krüppel样转录因子在维持细胞功能方面很重要。Krüppel样转录因子的缺失通常会导致胚胎发育异常甚至胚胎死亡。KLF4是该家族的一个重要成员，胚胎期KLF4的缺失会导致皮肤通透性改变和出生后死亡。除了在胚胎发育中的重要作用外，它在炎症和恶性肿瘤中也起着关键作用。已有研究表明，KLF4在多种癌症中具有调节作用，包括肺癌、乳腺癌、前列腺癌、结直肠癌、胰腺癌、肝细胞癌、卵巢癌、食管癌、膀胱癌和脑癌。然而，KLF4在肿瘤发生中的作用是复杂的，这可能与其具有转录激活和转录抑制结构域的独特结构以及对其上游和下游信号分子的调节有关。在这篇综述中，我们将总结KLF4的结构和功能方面，重点关注KLF4作为不同类型肿瘤的临床生物标志物和治疗靶点。
