Turkmen Sariyildiz Gulcin, Cicek Demir Canan, Demir Mehmet Emin, Arslan Aykut İlker, Banli Oktay, Dursun Ali Doğan
Operating Room Services, Vocational School of Health Services, Atilim University, Ankara, Turkey.
Department of General Surgery, Medicana International Ankara Hospital, Ankara, Turkey.
Int J Gen Med. 2023 Oct 19;16:4737-4744. doi: 10.2147/IJGM.S436213. eCollection 2023.
The excessive accumulation of fat tissue in obesity is the source of chronic low-level inflammation and causes future dysmetabolic and cardiovascular disorders. Removal of this excessive fat tissue with the aid of bariatric surgery (BS) techniques, such as sleeve gastrectomy, may reverse adverse inflammatory outcomes. The aim of this study is to investigate the impact of sleeve gastrectomy on inflammatory markers, specifically endocan, IL-6, and CRP, in individuals with obesity.
Thirty-two patients with class 3 obesity and class 2 obesity + comorbidities were enrolled in the study. Clinical characteristics including age, comorbidity, body mass index (BMI), waist, and hip circumferences of the participants were noted before and 3 months after sleeve gastrectomy. Blood samples were collected during those periods to assess biochemical features such as serum endocan, interleukin-6 (IL-6), C-reactive peptide, fasting insulin, glycosylated hemoglobin A1c levels, and lipid panel. A statistical package program was used for the analysis of those parameters, and p<0.05 was accepted as significant at a 95.0% confidence interval.
BMI reduced from 43.55±6.78 to 36.16±6.14 kg/m2 within 3 months following BS (p<0.001). Preoperative serum endocan, IL-6, and CRP levels were correlated with BMI, and in line with BMI reduction, their serum levels decreased after BS (p<0.05). HOMA-IR also reduced after BS, and both in the pre and post-BS periods correlated with BMI, IL-6, endocan, and CRP levels (p<0.05). The mean total body weight loss was 20.4% within 3 months post-BS.
BS techniques are effective in weight loss and reversing the inflammatory processes caused by obesity. Serum endocan, IL-6, and CRP levels are promising markers for describing obesity-related inflammation and objectively checking the alleviation of inflammation following BS.
肥胖症中脂肪组织的过度积累是慢性低度炎症的来源，并会导致未来的代谢紊乱和心血管疾病。借助减肥手术（BS）技术，如袖状胃切除术，去除这种过多的脂肪组织可能会逆转不良的炎症结果。本研究的目的是调查袖状胃切除术对肥胖个体炎症标志物，特别是内脂素、白细胞介素-6（IL-6）和C反应蛋白（CRP）的影响。
32例3级肥胖和2级肥胖合并症患者纳入本研究。记录参与者在袖状胃切除术前和术后3个月的临床特征，包括年龄、合并症、体重指数（BMI）、腰围和臀围。在这些时间段采集血样，以评估生化指标，如血清内脂素、白细胞介素-6（IL-6）、C反应蛋白、空腹胰岛素、糖化血红蛋白A1c水平和血脂谱。使用统计软件包程序分析这些参数，在95.0%置信区间内，p<0.05被认为具有统计学意义。
BS术后3个月内，BMI从43.55±6.78降至36.16±6.14kg/m²（p<0.001）。术前血清内脂素、IL-6和CRP水平与BMI相关，与BMI降低一致，BS术后其血清水平下降（p<0.05）。BS术后HOMA-IR也降低，且在BS术前和术后均与BMI、IL-6、内脂素和CRP水平相关（p<0.05）。BS术后3个月内平均总体重减轻20.4%。
BS技术在减肥和逆转肥胖引起的炎症过程方面是有效的。血清内脂素、IL-6和CRP水平是描述肥胖相关炎症和客观检查BS后炎症缓解情况的有前景的标志物。
