Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia.
Medicina (Kaunas). 2023 Apr 12;59(4):751. doi: 10.3390/medicina59040751.
: Obesity is a chronic inflammatory condition and is considered a major risk factor for cardiovascular disease (CVD). The effects of obesity management via sleeve gastrectomy (SG) and lifestyle intervention (LS) on inflammatory cytokines, redox status, and CVD risk were studied in this work. : A total of 92 participants (18 to 60 years old) with obesity (BMI ≥ 35 kg/m were divided into two groups: the bariatric surgery (BS) group ( = 30), and the LS group ( = 62). According to the achievement of 7% weight loss after 6 months, the participants were allocated to either the BS group, the weight loss (WL) group, or the weight resistance (WR) group. Assessments were performed for body composition (by bioelectric impedance), inflammatory markers (by ELISA kits), oxidative stress (OS), antioxidants (by spectrophotometry), and CVD risk (by the Framingham risk score (FRS) and lifetime atherosclerotic cardiovascular disease risk (ASCVD)). Measurements were taken before and after six months of either SG or LS (500 kcal deficit balanced diet, physical activity, and behavioral modification). : At the final assessment, only 18 participants in the BS group, 14 participants in the WL group, and 24 participants in the WR group remained. The loss in fat mass (FM) and weight loss were greatest in the BS group ( < 0.0001). Levels of IL-6, TNF-a, MCP-1, CRP, and OS indicators were significantly reduced in the BS and WL groups. The WR group had significant change only in MCP-1 and CRP. Significant reductions in the CVD risk in the WL and BS groups were detected only when using FRS rather than ASCVD. The FM loss correlated inversely with FRS-BMI and ASCVD in the BS group, whereas in the WL group, FM loss correlated only with ASCVD. : BS produced superior weight and fat mass loss. However, both BS and LS produced a similar reduction in the inflammatory cytokines, relief of OS indicators, and enhancement of antioxidant capacity, and consequently reduced the CVD risk.
肥胖是一种慢性炎症状态，被认为是心血管疾病（CVD）的主要危险因素。本研究旨在探讨袖状胃切除术（SG）和生活方式干预（LS）对肥胖管理的影响，以及对炎症细胞因子、氧化还原状态和 CVD 风险的影响。
共有 92 名肥胖患者（BMI≥35kg/m）（18 至 60 岁）被分为两组：减重手术（BS）组（n=30）和 LS 组（n=62）。根据 6 个月后体重减轻 7%的结果，将患者分为 BS 组、体重减轻（WL）组或体重抵抗（WR）组。通过生物电阻抗法评估身体成分，通过 ELISA 试剂盒评估炎症标志物，通过分光光度法评估氧化应激和抗氧化剂，通过 Framingham 风险评分（FRS）和终身动脉粥样硬化性心血管疾病风险（ASCVD）评估 CVD 风险。在接受 SG 或 LS 治疗 6 个月前后进行了这些测量（500 千卡热量不足的均衡饮食、体育活动和行为改变）。
在最终评估时，BS 组仅 18 名、WL 组 14 名和 WR 组 24 名患者完成了研究。BS 组的体脂（FM）损失和体重减轻最大（<0.0001）。BS 和 WL 组的 IL-6、TNF-a、MCP-1、CRP 和 OS 指标水平显著降低。WR 组仅在 MCP-1 和 CRP 方面有显著变化。只有在使用 FRS 而不是 ASCVD 时，WL 和 BS 组的 CVD 风险才显著降低。BS 组的 FM 损失与 FRS-BMI 和 ASCVD 呈负相关，而 WL 组的 FM 损失仅与 ASCVD 相关。
BS 可显著减轻体重和体脂，但 BS 和 LS 均可显著降低炎症细胞因子水平，减轻氧化应激指标，增强抗氧化能力，从而降低 CVD 风险。
