• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

How defective mitochondrial electrical activity leads to inherited blindness.

作者信息

Burke Peter J

机构信息

Department of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697.

Department of Biomedical Engineering, University of California, Irvine, CA 92697.

出版信息

Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2315649120. doi: 10.1073/pnas.2315649120. Epub 2023 Oct 25.

DOI:10.1073/pnas.2315649120
PMID:37878684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10636301/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2476/10636301/c7d5f1da407d/pnas.2315649120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2476/10636301/c7d5f1da407d/pnas.2315649120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2476/10636301/c7d5f1da407d/pnas.2315649120fig01.jpg

相似文献

1
How defective mitochondrial electrical activity leads to inherited blindness.线粒体电活动缺陷如何导致遗传性失明。
Proc Natl Acad Sci U S A. 2023 Nov 7;120(45):e2315649120. doi: 10.1073/pnas.2315649120. Epub 2023 Oct 25.
2
Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.通过靶向序列修饰的腺相关病毒将突变型烟酰胺腺嘌呤二核苷酸脱氢酶亚基4基因递送至线粒体可导致小鼠视力丧失和视神经萎缩。
Mol Vis. 2012;18:1668-83. Epub 2012 Jun 20.
3
Leber hereditary optic neuropathy--a disease with a known molecular basis but a mysterious mechanism of pathology.
J Appl Genet. 2003;44(4):529-38.
4
Familial optic atrophy with white matter changes.
Am J Med Genet A. 2003 Sep 1;121A(3):263-5. doi: 10.1002/ajmg.a.20238.
5
Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme.线粒体复合体I的ND6亚基中的Leber遗传性视神经病变突变影响该酶细菌模型中的泛醌还原动力学。
Biochem J. 2008 Jan 1;409(1):129-37. doi: 10.1042/BJ20070866.
6
Pathologically Responsive Mitochondrial Gene Therapy in an Allotopic Expression-Independent Manner Cures Leber's Hereditary Optic Neuropathy.病理性反应性线粒体基因治疗以异位表达非依赖性方式治愈莱伯遗传性视神经病变。
Adv Mater. 2021 Oct;33(41):e2103307. doi: 10.1002/adma.202103307. Epub 2021 Aug 25.
7
Is there treatment for Leber hereditary optic neuropathy?对于Leber遗传性视神经病变有治疗方法吗?
Curr Opin Ophthalmol. 2015 Nov;26(6):450-7. doi: 10.1097/ICU.0000000000000212.
8
High Mitochondrial DNA Copy Number Is a Protective Factor From Vision Loss in Heteroplasmic Leber's Hereditary Optic Neuropathy (LHON).高线粒体DNA拷贝数是异质性Leber遗传性视神经病变(LHON)中视力丧失的保护因素。
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2193-2197. doi: 10.1167/iovs.16-20389.
9
Topiramate and visual loss in a patient carrying a Leber hereditary optic neuropathy mutation.患者携带莱伯遗传性视神经病变突变致托吡酯相关视力丧失
Neurol Sci. 2012 Apr;33(2):419-21. doi: 10.1007/s10072-011-0755-5. Epub 2011 Sep 7.
10
Leber Hereditary Optic Neuropathy-Light at the End of the Tunnel?Leber 遗传性视神经病变——隧道尽头的光?
Asia Pac J Ophthalmol (Phila). 2018 Jul-Aug;7(4):242-245. doi: 10.22608/APO.2018293. Epub 2018 Jul 15.

引用本文的文献

1
Quantitative measurements of reactive oxygen species partitioning in electron transfer flavoenzyme magnetic field sensing.电子传递黄素酶磁场传感中活性氧物种分配的定量测量。
Front Physiol. 2024 Feb 2;15:1348395. doi: 10.3389/fphys.2024.1348395. eCollection 2024.

本文引用的文献

1
Coenzyme Q10 trapping in mitochondrial complex I underlies Leber's hereditary optic neuropathy.辅酶 Q10 在线粒体复合物 I 中的捕获是莱伯遗传性视神经病变的基础。
Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2304884120. doi: 10.1073/pnas.2304884120. Epub 2023 Sep 21.
2
Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput.亚细胞组学:推动分辨率、复杂性和通量极限的新前沿。
Nat Methods. 2023 Mar;20(3):331-335. doi: 10.1038/s41592-023-01788-0.
3
Hallmarks of aging: An expanding universe.衰老的特征:一个不断扩大的领域。
Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3.
4
Modeling Reactive Oxygen Species-Induced Axonal Loss in Leber Hereditary Optic Neuropathy.构建活性氧诱导的莱伯遗传性视神经病变轴突丢失模型。
Biomolecules. 2022 Oct 2;12(10):1411. doi: 10.3390/biom12101411.
5
A Three-Dimensional Printed Inertial Microfluidic Platform for Isolation of Minute Quantities of Vital Mitochondria.一种用于分离微量重要线粒体的三维打印惯性微流控平台。
Anal Chem. 2022 May 17;94(19):6930-6938. doi: 10.1021/acs.analchem.1c03244. Epub 2022 May 3.
6
Assocation Between Leber's Hereditary Optic Neuropathy and MT-ND1 3460G>A Mutation-Induced Alterations in Mitochondrial Function, Apoptosis, and Mitophagy.Leber 遗传性视神经病变与 MT-ND1 3460G>A 突变诱导的线粒体功能、细胞凋亡和自噬改变的关联。
Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):38. doi: 10.1167/iovs.62.9.38.
7
Key role of quinone in the mechanism of respiratory complex I.醌在呼吸复合物 I 机制中的关键作用。
Nat Commun. 2020 Aug 18;11(1):4135. doi: 10.1038/s41467-020-17957-0.
8
Resistive flow sensing of vital mitochondria with nanoelectrodes.纳米电极对重要线粒体的电阻式流量感应。
Mitochondrion. 2017 Nov;37:8-16. doi: 10.1016/j.mito.2017.06.003. Epub 2017 Jun 24.
9
The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics.活性氧物种分配的量子生物学影响细胞生物能学。
Sci Rep. 2016 Dec 20;6:38543. doi: 10.1038/srep38543.
10
Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization.嵴重塑导致在线粒体外膜通透性改变期间被集成石墨烯传感器检测到的酸化。
Sci Rep. 2016 Oct 27;6:35907. doi: 10.1038/srep35907.