Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China.
Biomed Pharmacother. 2023 Dec;168:115765. doi: 10.1016/j.biopha.2023.115765. Epub 2023 Oct 24.
Heart failure has become a public health problem that we cannot avoid choosing to face in today's context. In the case of heart failure, pathological cardiac hypertrophy plays a major role because of its condition of absolute increase in ventricular mass under various stresses. Ferroptosis, it could be defined as regulatory mechanisms that regulate cell death in the absence of apoptosis in iron-dependent cells. This paper introduces various new research findings on the use of different regulatory mechanisms of cellular ferroptosis for the treatment of heart failure and cardiac hypertrophy, providing new therapeutic targets and research directions for clinical treatment. The role and mechanism of ferroptosis in the field of heart failure has been increasingly demonstrated, and the relationship between cardiac hypertrophy, which is one of the causes of heart failure, is also an area of research that we should focus on. In addition, the latest applications and progress of inducers and inhibitors of ferroptosis are reported in this paper, updating the breakthroughs in their fields.
心力衰竭已成为我们在当今环境下无法回避的公共卫生问题。在心力衰竭的情况下，病理性心肌肥厚因其在各种应激下心室质量绝对增加的情况而起着主要作用。铁死亡可以被定义为在铁依赖性细胞中没有凋亡的情况下调节细胞死亡的调节机制。本文介绍了使用不同的细胞铁死亡调节机制治疗心力衰竭和心肌肥厚的各种新研究发现，为临床治疗提供了新的治疗靶点和研究方向。铁死亡在心力衰竭领域的作用和机制已得到越来越多的证明，而心力衰竭的一个原因——心肌肥厚的关系也是我们应该关注的研究领域。此外，本文还报道了铁死亡诱导剂和抑制剂的最新应用和进展，更新了其领域的突破。
