代谢与心肌病：从分子机制到治疗见解

Metrnl and Cardiomyopathies: From Molecular Mechanisms to Therapeutic Insights.

作者信息

Xu Miaomiao, Liu Xiaoguang, Lu Liming, Li Zhaowei

机构信息

School of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.

出版信息

J Cell Mol Med. 2025 Jan;29(2):e70371. doi: 10.1111/jcmm.70371.

DOI:10.1111/jcmm.70371

PMID:39853716

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11756984/

Abstract

Cardiomyopathies, a diverse group of diseases affecting the heart muscle, continue to pose significant clinical challenges due to their complex aetiologies and limited treatment options targeting underlying genetic and molecular dysregulations. Emerging evidence indicates that Metrnl, a myokine, adipokine and cardiokine, plays a significant role in the pathogenesis of various cardiomyopathies. Therefore, the objective of this review is to examine the role and mechanism of Metrnl in various cardiomyopathies, with the expectation of providing new insights for the treatment of these diseases.

摘要

心肌病是一组影响心肌的多种疾病，由于其病因复杂且针对潜在基因和分子失调的治疗选择有限，仍然构成重大的临床挑战。新出现的证据表明，Metrnl作为一种肌动蛋白、脂肪因子和心脏因子，在各种心肌病的发病机制中发挥着重要作用。因此，本综述的目的是探讨Metrnl在各种心肌病中的作用和机制，以期为这些疾病的治疗提供新的见解。