• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Psoriatic Neutrophils Are Primed in Circulation for Enhanced β-Integrin-Dependent Recruitment and Effector Function on E-Selectin and ICAM-1.

作者信息

Garcia Gustavo, Chen Szu Jung, Westerland Megan R, Wu Xuesong, Hwang Samuel T, Simon Scott I

机构信息

Department of Biomedical Engineering, University of California, Davis, Davis, California, USA.

Department of Dermatology, University of California, Davis, California, USA.

出版信息

J Invest Dermatol. 2024 Apr;144(4):901-905.e4. doi: 10.1016/j.jid.2023.09.281. Epub 2023 Oct 23.

DOI:10.1016/j.jid.2023.09.281
PMID:37879398
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11171442/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabf/11171442/bfb544b90362/nihms-1990050-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabf/11171442/60178164de32/nihms-1990050-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabf/11171442/bfb544b90362/nihms-1990050-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabf/11171442/60178164de32/nihms-1990050-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dabf/11171442/bfb544b90362/nihms-1990050-f0002.jpg

相似文献

1
Psoriatic Neutrophils Are Primed in Circulation for Enhanced β-Integrin-Dependent Recruitment and Effector Function on E-Selectin and ICAM-1.银屑病中性粒细胞在循环中被预激活，以增强β整合素依赖性募集及在E选择素和细胞间黏附分子-1上的效应功能。
J Invest Dermatol. 2024 Apr;144(4):901-905.e4. doi: 10.1016/j.jid.2023.09.281. Epub 2023 Oct 23.
2
Neutrophil tethering on E-selectin activates beta 2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway.中性粒细胞在E-选择素上的锚定通过丝裂原活化蛋白激酶信号转导途径激活β2整合素与细胞间黏附分子-1（ICAM-1）的结合。
J Immunol. 2000 Apr 15;164(8):4348-58. doi: 10.4049/jimmunol.164.8.4348.
3
The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils.中性粒细胞上 E-选择素和 P-选择素诱导的整合素 αLβ2 中间激活的动力学。
J Cell Sci. 2021 Sep 15;134(18). doi: 10.1242/jcs.258046. Epub 2021 Sep 23.
4
Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils.E选择素对L选择素和P选择素糖蛋白配体1的剪切依赖性封端信号激活中性粒细胞上的高亲和力β2整合素。
J Immunol. 2004 Jun 15;172(12):7780-90. doi: 10.4049/jimmunol.172.12.7780.
5
Beta2-integrins mediate stable adhesion in collisional interactions between neutrophils and ICAM-1-expressing cells.β2整合素在中性粒细胞与表达细胞间黏附分子-1（ICAM-1）的细胞发生碰撞相互作用时介导稳定黏附。
J Leukoc Biol. 1998 Nov;64(5):622-30. doi: 10.1002/jlb.64.5.622.
6
Stimulation of P-selectin glycoprotein ligand-1 on mouse neutrophils activates beta 2-integrin mediated cell attachment to ICAM-1.刺激小鼠中性粒细胞上的P-选择素糖蛋白配体-1会激活β2整合素介导的细胞与细胞间黏附分子-1的附着。
Eur J Immunol. 1998 Feb;28(2):433-43. doi: 10.1002/(SICI)1521-4141(199802)28:02<433::AID-IMMU433>3.0.CO;2-U.
7
Neutrophil CD18-dependent arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow can be activated through L-selectin.中性粒细胞通过L-选择素可激活其在剪切流中依赖CD18的对细胞间黏附分子1（ICAM-1）的黏附。
J Immunol. 1997 Jan 1;158(1):367-75.
8
Cooperativity between selectins and beta2-integrins define neutrophil capture and stable adhesion in shear flow.选择素与β2整合素之间的协同作用决定了中性粒细胞在剪切流中的捕获和稳定黏附。
Ann Biomed Eng. 2004 Sep;32(9):1179-92. doi: 10.1114/b:abme.0000039352.11428.9d.
9
Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1.在缺乏E-、P-和L-选择素以及细胞间黏附分子-1（ICAM-1）的小鼠中，不依赖选择素的白细胞滚动和黏附
Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H634-41. doi: 10.1152/ajpheart.2001.280.2.H634.
10
Peroxynitrite induces integrin-dependent adhesion of human neutrophils to endothelial cells via activation of the Raf-1/MEK/Erk pathway.过氧亚硝酸盐通过激活Raf-1/MEK/Erk信号通路诱导人中性粒细胞与内皮细胞发生整合素依赖性黏附。
FASEB J. 2001 Jan;15(1):25-27. doi: 10.1096/fj.00-0521fje. Epub 2000 Nov 9.

引用本文的文献

1
Psoriasis: A Multidimensional Review of Onset, Progression, Treatment, and the Evolution of Disease Models.银屑病：关于发病、进展、治疗及疾病模型演变的多维度综述
Mol Diagn Ther. 2025 May;29(3):345-366. doi: 10.1007/s40291-025-00776-8. Epub 2025 Apr 1.
2
Key genes and immune infiltration patterns and the clinical implications in psoriasis patients.银屑病患者的关键基因和免疫浸润模式及其临床意义。
Skin Res Technol. 2024 Aug;30(8):e13889. doi: 10.1111/srt.13889.

本文引用的文献

1
Impact of ROS-Dependent Lipid Metabolism on Psoriasis Pathophysiology.ROS 依赖性脂质代谢对银屑病发病机制的影响。
Int J Mol Sci. 2022 Oct 12;23(20):12137. doi: 10.3390/ijms232012137.
2
Association of S100A8/A9 with Lipid-Rich Necrotic Core and Treatment with Biologic Therapy in Patients with Psoriasis: Results from an Observational Cohort Study.S100A8/A9 与富含脂质的坏死核心的关联及其在银屑病患者生物治疗中的作用：一项观察性队列研究的结果。
J Invest Dermatol. 2022 Nov;142(11):2909-2919. doi: 10.1016/j.jid.2022.05.1085. Epub 2022 Jun 21.
3
Stratum corneum levels of calprotectin proteins S100A8/A9 correlate with disease activity in psoriasis patients.角质层中钙卫蛋白 S100A8/A9 水平与银屑病患者的疾病活动度相关。
J Dermatol. 2021 Oct;48(10):1518-1525. doi: 10.1111/1346-8138.16032. Epub 2021 Jun 24.
4
The TNF/IL-23/IL-17 axis-Head-to-head trials comparing different biologics in psoriasis treatment.TNF/IL-23/IL-17 轴——头对头试验比较不同生物制剂治疗银屑病的疗效。
Scand J Immunol. 2020 Oct;92(4):e12946. doi: 10.1111/sji.12946.
5
Role of Neutrophils in Psoriasis.中性粒细胞在银屑病中的作用。
J Immunol Res. 2020 Jun 5;2020:3709749. doi: 10.1155/2020/3709749. eCollection 2020.
6
Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk.中性粒细胞胞外诱捕网通过激活表皮 TLR4/IL-36R 串扰促进银屑病的炎症反应。
Front Immunol. 2019 Apr 5;10:746. doi: 10.3389/fimmu.2019.00746. eCollection 2019.
7
Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow.选择素捕获键在剪切流作用下介导整联蛋白激活以及中性粒细胞在炎症内皮上的黏附。
Blood. 2017 Nov 9;130(19):2101-2110. doi: 10.1182/blood-2017-05-783027. Epub 2017 Aug 15.
8
Multiple Phenotypic Changes Define Neutrophil Priming.多种表型变化定义了中性粒细胞的预激活。
Front Cell Infect Microbiol. 2017 May 29;7:217. doi: 10.3389/fcimb.2017.00217. eCollection 2017.
9
Extracellular MRP8/14 is a regulator of β2 integrin-dependent neutrophil slow rolling and adhesion.细胞外的MRP8/14是β2整合素依赖性中性粒细胞缓慢滚动和黏附的调节因子。
Nat Commun. 2015 Apr 20;6:6915. doi: 10.1038/ncomms7915.
10
Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.Orai1 在剪切流中调节中性粒细胞募集过程中的细胞内钙、阻滞和形态极化。
Blood. 2010 Jan 21;115(3):657-66. doi: 10.1182/blood-2009-05-224659. Epub 2009 Nov 20.