McMaster University, Department of Medicine, Hamilton, Canada; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; McMaster Institute for Research on Ageing, McMaster University, Hamilton, Ontario, Canada.
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; McMaster Institute for Research on Ageing, McMaster University, Hamilton, Ontario, Canada; Labarge Centre for Mobility in Aging, McMaster University, Hamilton, Ontario, Canada.
Respir Med. 2023 Nov-Dec;219:107431. doi: 10.1016/j.rmed.2023.107431. Epub 2023 Oct 24.
Chronic cough is a common troublesome condition, but it is unclear whether dry or productive chronic cough and sex, impacts the burden of cough differently.
The Canadian Longitudinal Study on Aging is a nationally generalizable, stratified random sample of adults aged 45-85 years. Chronic cough was identified based on a self-reported daily cough in the last 12 months assessed at baseline (2011-2015) and follow-up (2015-2018). Odds ratios (95 % CI) for cough status and change in social participation activities (SPA), healthcare resource utilisation (HCRU), basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) were estimated using a weighted generalised estimating equation (WGEE). Results were stratified by sex, and adjusted for age, sex, smoking, body mass index, education, respiratory diseases and retirement status.
Overall, chronic cough was associated with less SPA, greater HCRU and impaired ADL/IADLs. Productive chronic cough in males was associated with SPA limited by health, ED visits and hospitalisation. Females with productive chronic cough was associated with reduced frequency of SPA and ED visit. Dry chronic cough in females was associated with SPA limited by health and ED visits. Both types of cough was associated with at least 1 impaired basic ADL, but only in females with productive chronic cough was there an association with any impairment in IADLs.
Chronic cough is associated with a greater burden on social participation, healthcare use and personal care.
慢性咳嗽是一种常见的麻烦病症，但目前尚不清楚干咳或湿咳以及性别是否会对咳嗽负担产生不同影响。
加拿大老龄化纵向研究是一项全国性的、分层随机抽样的、年龄在 45-85 岁的成年人研究。慢性咳嗽是根据基线（2011-2015 年）和随访（2015-2018 年）期间过去 12 个月内每日咳嗽的自我报告来确定的。使用加权广义估计方程（WGEE）估计咳嗽状况和社会参与活动（SPA）、医疗保健资源利用（HCRU）、基本日常生活活动（ADLs）和工具性日常生活活动（IADLs）变化的比值比（95%置信区间）。结果按性别分层，并根据年龄、性别、吸烟、体重指数、教育程度、呼吸疾病和退休状况进行调整。
总体而言，慢性咳嗽与 SPA 减少、HCRU 增加和 ADL/IADL 受损有关。男性湿咳与 SPA 受限（健康相关）、急诊就诊和住院有关。女性湿咳与 SPA 频率降低和急诊就诊有关。女性干咳与 SPA 受限（健康相关）和急诊就诊有关。两种类型的咳嗽都至少与一项基本 ADL 受损有关，但只有女性湿咳与 IADL 受损有关。
慢性咳嗽与社会参与、医疗保健利用和个人护理负担增加有关。
