Hai Sirao, Zhao Jie, Chen Chuangjiang, Wang Chenlong, Ma Li, Rahman Sajid Ur, Zhao Chang, Feng Shibin, Wu Jinjie, Wang Xichun
College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China.
College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei, 230036, China; Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.
Food Chem Toxicol. 2023 Dec;182:114110. doi: 10.1016/j.fct.2023.114110. Epub 2023 Oct 23.
Zearalenone (ZEA) is widely present in food and feed, and pigs are susceptible to its effects. This study explored the underlying function of ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) through activation of the JNK signaling pathway and mitochondrial division. This study utilized ESCs to explore the impact of exposure to ZEA. A mitochondrial division inhibitor (Mdivi) was also included as a reference. The results indicated a gradual decrease in cell viability with increasing ZEA concentration. In addition, ZEA can modify the growth status of porcine ESCs, disrupt their ultrastructure, and lead to apoptosis of porcine ESCs via the mitochondrial division pathway and JNK signaling pathway. In summary, our study found the critical targets of ZEA infected with pig ESCs, which provided a conceptual foundation to prevent and control ZEA.
玉米赤霉烯酮（ZEA）广泛存在于食品和饲料中，猪对其影响敏感。本研究通过激活JNK信号通路和线粒体分裂，探讨ZEA诱导猪子宫内膜基质细胞（ESCs）凋亡的潜在机制。本研究利用ESCs探究ZEA暴露的影响。还加入了线粒体分裂抑制剂（Mdivi）作为对照。结果表明，随着ZEA浓度的增加，细胞活力逐渐降低。此外，ZEA可改变猪ESCs的生长状态，破坏其超微结构，并通过线粒体分裂途径和JNK信号通路导致猪ESCs凋亡。总之，我们的研究发现了ZEA感染猪ESCs的关键靶点，为ZEA的防控提供了理论基础。
