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Unexpected cause of Kounis syndrome: hypersensitivity reaction to omeprazole.Kounis 综合征的意外病因:奥美拉唑过敏反应。
BMJ Case Rep. 2023 Oct 24;16(10):e254799. doi: 10.1136/bcr-2023-254799.
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Nine cases of omeprazole allergy: cross-reactivity between proton pump inhibitors.9例奥美拉唑过敏:质子泵抑制剂之间的交叉反应性
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Kounis syndrome following allergy injection in a paediatric patient.儿童患者接受过敏注射后发生 Kounis 综合征。
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[Immediate type reactions to proton pump inhibitors using pantoprazole and omeprazole as examples].[以泮托拉唑和奥美拉唑为例的质子泵抑制剂速发型反应]
Hautarzt. 2018 Feb;69(2):162-164. doi: 10.1007/s00105-017-4075-4.
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Recurrent Coronary Vasospasm: A Case of Kounis Syndrome from Anaphylaxis to Contrast Dye.复发性冠状动脉痉挛:一例由造影剂过敏引发的 Kounis 综合征。
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Cases of allergic coronary syndrome (Kounis syndrome) : what we should know.过敏性冠状动脉综合征(寇恩斯综合征)病例:我们应该知道什么。
Nagoya J Med Sci. 2022 Aug;84(3):664-672. doi: 10.18999/nagjms.84.3.664.
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Kounis syndrome following an anaphylactic reaction to antivenom in a patient with Russell's viper (Daboia russelii) bite: A case report.患者被罗素蝰蛇(Daboia russelii)咬伤后发生抗蛇毒血清过敏反应致 Kounis 综合征:病例报告。
Toxicon. 2022 Oct 30;218:66-69. doi: 10.1016/j.toxicon.2022.09.006. Epub 2022 Sep 13.
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Kounis syndrome, a disease to know: Case report and review of the literature.认识库尼斯综合征:病例报告及文献综述
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Anaphylactic cardiovascular collapse manifesting as myocardial infarction following salad consumption. A case of Kounis variant type I syndrome.食用沙拉后表现为心肌梗死的过敏性心血管衰竭。一例 Kounis 变异型 I 综合征。
Acta Biomed. 2020 Mar 19;91(1):134-138. doi: 10.23750/abm.v91i1.8176.

本文引用的文献

1
Kounis syndrome: from an unexpected case in the Emergency Room to a review of the literature.Kounis 综合征:从急诊室的一个意外病例到文献复习。
Acta Biomed. 2022 Mar 14;93(1):e2022002. doi: 10.23750/abm.v93i1.11862.
2
Reply to the letter: "Kounis syndrome: Towards a new classification".对信件《库尼斯综合征:迈向新分类》的回复
Int J Cardiol. 2021 Jul 15;335:25. doi: 10.1016/j.ijcard.2021.04.041. Epub 2021 Apr 28.
3
Kounis syndrome: a clinical entity penetrating from pediatrics to geriatrics.库尼斯综合征:一种贯穿儿科至老年科的临床病症。
J Geriatr Cardiol. 2020 May;17(5):294-299. doi: 10.11909/j.issn.1671-5411.2020.05.011.
4
Acute coronary syndrome secondary to allergic coronary vasospasm (Kounis Syndrome): a case series, follow-up and literature review.过敏性冠状动脉痉挛继发急性冠状动脉综合征(库尼斯综合征):病例系列、随访及文献综述
BMC Cardiovasc Disord. 2018 Feb 27;18(1):42. doi: 10.1186/s12872-018-0781-9.
5
[A case of acute coronary syndrome following the use of parenteral penicillin: Kounis syndrome].[静脉注射青霉素后发生急性冠状动脉综合征一例:库尼斯综合征]
Turk Kardiyol Dern Ars. 2012 Oct;40(7):615-9. doi: 10.5543/tkda.2012.54077.
6
Kounis syndrome: a new twist on an old disease.库尼斯综合征:一种旧病的新情况。
Future Cardiol. 2011 Nov;7(6):805-24. doi: 10.2217/fca.11.63.
7
Hypersensitivity to proton pump inhibitors: lansoprazole-induced Kounis syndrome.质子泵抑制剂过敏:兰索拉唑诱导的 Kounis 综合征。
Int J Cardiol. 2009 May 29;134(3):e94-6. doi: 10.1016/j.ijcard.2007.12.099. Epub 2008 Apr 2.
8
Cefuroxime-induced coronary artery spasm manifesting as Kounis syndrome.头孢呋辛引起的冠状动脉痉挛表现为库尼斯综合征。
Acta Cardiol. 2005 Jun;60(3):341-5. doi: 10.2143/AC.60.3.2005015.
9
Unstable angina, allergic angina, and allergic myocardial infarction.不稳定型心绞痛、变异性心绞痛和变异性心肌梗死。
Circulation. 1999 Dec 21;100(25):e156. doi: 10.1161/01.cir.100.25.e156.

Kounis 综合征的意外病因:奥美拉唑过敏反应。

Unexpected cause of Kounis syndrome: hypersensitivity reaction to omeprazole.

机构信息

Cardiology, Istanbul Sultan II Abdulhamid Han Egitim ve Arastirma Hastanesi, Istanbul, Turkey.

İnternal Medicine, University of Maryland Midtown Campus, Baltimore, Maryland, USA.

出版信息

BMJ Case Rep. 2023 Oct 24;16(10):e254799. doi: 10.1136/bcr-2023-254799.

DOI:10.1136/bcr-2023-254799
PMID:37879707
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10603422/
Abstract

Kounis syndrome is a rare type of acute coronary syndrome (ACS) that occurs as a result of an allergic or anaphylactic reaction. Kounis syndrome can be induced by various medications including antibiotics, proton pump inhibitors, antihypertensive medications, corticosteroids, and antineoplastic medications. Additionally, cases of Kounis syndrome associated with lansoprazole and pantoprazole have been previously reported in the literature. In this report, we present a case of Kounis syndrome associated with omeprazole use, and discuss the need for a high index of suspicion as it is often underrecognised.

摘要

库恩斯综合征是一种罕见的急性冠状动脉综合征(ACS),是由于过敏或过敏反应引起的。库恩斯综合征可由各种药物引起,包括抗生素、质子泵抑制剂、降压药物、皮质类固醇和抗肿瘤药物。此外,文献中先前曾报道过与兰索拉唑和泮托拉唑相关的库恩斯综合征病例。在本报告中,我们介绍了一例与奥美拉唑使用相关的库恩斯综合征病例,并讨论了需要高度怀疑的必要性,因为它常常被低估。