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有机磷中毒后儿童迟发性脊髓病。

Delayed myelopathy in a child following organic phosphate poisoning.

机构信息

Department of Child Health, Sultan Qaboos University, Muscat, Oman.

Department of Child Health, Sultan Qaboos University, Muscat, Oman

出版信息

BMJ Case Rep. 2023 Oct 24;16(10):e253456. doi: 10.1136/bcr-2022-253456.

Abstract

We report a rare manifestation of delayed organophosphate (OP) poisoning in a male patient in his early childhood. After initially presenting with a cholinergic crisis after OP exposure, the patient returned 3 weeks later with paraparesis and difficulty with bladder control. The results of the MRI of the spine and brain as well as the nerve conduction studies were normal. Myelopathy induced by OP poisoning should be considered in any patient with a history of OP exposure and a presentation of paraparesis. At most recent follow-up, the patient had full bladder control and could walk without assistance. However, he demonstrated circumduction while walking with upper motor neuron signs. Furthermore, he had mild Achilles tendon contractures on both sides. To enable early detection, neurologists and paediatricians should be aware of this uncommon complication of OP poisoning which may influence neurological outcome.

摘要

我们报告了一例罕见的儿童期男性迟发性有机磷(OP)中毒病例。该患者最初在接触 OP 后出现胆碱能危象,3 周后出现截瘫和膀胱控制困难。脊柱和脑部 MRI 以及神经传导研究结果正常。任何有 OP 暴露史和截瘫表现的患者,都应考虑 OP 中毒引起的脊髓病。在最近的随访中,患者膀胱完全控制,可以无需帮助行走。但他在行走时表现出回旋运动,伴有上运动神经元征。此外,他两侧跟腱都有轻度挛缩。为了实现早期检测,神经科医生和儿科医生应意识到 OP 中毒的这种罕见并发症,这可能会影响神经功能结局。

相似文献

本文引用的文献

1
Delayed myelopathy after organophosphate intoxication: A case report.有机磷中毒后迟发性脊髓病:一例报告。
SAGE Open Med Case Rep. 2022 Jun 16;10:2050313X221104309. doi: 10.1177/2050313X221104309. eCollection 2022.
8
Organophosphorus ester-induced chronic neurotoxicity.有机磷酸酯诱导的慢性神经毒性。
Arch Environ Health. 2003 Aug;58(8):484-97. doi: 10.3200/AEOH.58.8.484-497.
10
Electrophysiological studies in acute organophosphate poisoning.急性有机磷中毒的电生理研究
J Neurol Neurosurg Psychiatry. 1987 Nov;50(11):1442-8. doi: 10.1136/jnnp.50.11.1442.

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