SOX10表达在预测胃癌神经侵犯中的价值。
The value of SOX10 expression in predicting perineural invasion in gastric cancer.
作者信息
Yazdi Seyed Amir Miratashi, Moghtadaie Atieh, Nazar Elham
机构信息
Department of General Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Rev Esp Patol. 2023 Oct-Dec;56(4):227-232. doi: 10.1016/j.patol.2023.05.003. Epub 2023 Sep 1.
BACKGROUND
SRY-related HMG-box 10 (SOX10) protein has a confirmed role in the regulation of neural cell proliferation and differentiation. It is now suggested that the changes in SOX10 expression may be linked to neural invasion by cancer cells. We aimed to assess the value of SOX10 expression in predicting perineural invasion in gastric cancer.
METHODS
A cross-sectional study was performed on 40 patients with gastric cancer. To assess perineural invasion, Hematoxylin & Eosin stained slides were examined. The expression of SOX10 was also examined by immunohistochemistry.
RESULTS
Our study showed higher perineural invasion in those with SOX10 positivity as compared to those without SOX10 expression (64.0% vs. 6.7%, p=0.001). No association was revealed between other baseline variables and SOX10 positivity. The expression of this marker increased the chance of neural invasion up to 17 times as indicated by the multivariable regression modeling. Multivariable regression modeling indicated that the chance of neural invasion increased up to 17 times in cases of SOX10 positivity.
CONCLUSION
Overexpression of SOX10 is closely associated with the risk of perineural invasion in gastric cancer.
背景
SRY相关高迁移率族蛋白盒10（SOX10）蛋白在神经细胞增殖和分化的调控中具有明确作用。目前认为，SOX10表达的变化可能与癌细胞的神经侵袭有关。我们旨在评估SOX10表达在预测胃癌神经周围侵犯中的价值。
方法
对40例胃癌患者进行了一项横断面研究。为评估神经周围侵犯情况，检查了苏木精-伊红染色切片。还通过免疫组织化学检查了SOX10的表达。
结果
我们的研究显示，与无SOX10表达的患者相比，SOX10阳性患者的神经周围侵犯更高（64.0%对6.7%，p = 0.001）。未发现其他基线变量与SOX10阳性之间存在关联。多变量回归模型显示，该标志物的表达使神经侵袭的几率增加至17倍。多变量回归模型表明，SOX10阳性病例中神经侵袭的几率增加至17倍。
结论
SOX10的过表达与胃癌神经周围侵犯的风险密切相关。
Zotero 插件