Li Jin, Wang Yan, Ma Jianxiong, Pang Xinxin, Zhou Wei, Tian Cungui, Yang Guohui, Zhao Na
Tianjin Hospital, Tianjin University, Tianjin 300211, P. R. China.
CNNC High Energy Equipment (Tianjin) Co., Ltd., Tianjin 300300, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Oct 25;40(5):982-988. doi: 10.7507/1001-5515.202305017.
Radiopharmaceutical dynamic imaging typically necessitates intravenous injection via the bolus method. However, manual bolus injection carries the risk of handling errors as well as radiological injuries. Hence, there is potential for automated injection devices to replace manual injection methods. In this study, the effect of micro-bolus pulse injection technology was compared and verified by radioactive experiments using a programmable injection pump, and the overall bubble recognition experiment and rat tail vein simulation injection verification were performed using the piezoelectric sensor preloading method. The results showed that at the same injection peak speed, the effective flushing volume of micro-bolus pulse flushing (about 83 μL/pulse) was 49.65% lower than that of uniform injection and 25.77% lower than that of manual flushing. In order to avoid the dilution effect of long pipe on the volume of liquid, the use of piezoelectric sensor for sealing preloading detection could accurately predict the bubbles of more than 100 μL in the syringe. In the simulated injection experiment of rat tail vein, when the needle was placed in different tissues by preloading 100 μL normal saline, the piezoelectric sensor fed back a large difference in pressure attenuation rate within one second, which was 2.78% in muscle, 17.28% in subcutaneous and 54.71% in vein. Micro-bolus pulse injection method and piezoelectric sensor sealing preloading method have application potential in improving the safety of radiopharmaceutical automatic bolus injection.
放射性药物动态成像通常需要通过团注法进行静脉注射。然而，手动团注注射存在操作失误以及放射性损伤的风险。因此，自动注射装置有取代手动注射方法的潜力。在本研究中，使用可编程注射泵通过放射性实验比较并验证了微团注脉冲注射技术的效果，并采用压电传感器预充液法进行了整体气泡识别实验和大鼠尾静脉模拟注射验证。结果表明，在相同的注射峰值速度下，微团注脉冲冲洗的有效冲洗体积（约83μL/脉冲）比均匀注射低49.65%，比手动冲洗低25.77%。为避免长管道对液体体积的稀释作用，采用压电传感器进行密封预充液检测可准确预测注射器中100μL以上的气泡。在大鼠尾静脉模拟注射实验中，通过预充100μL生理盐水将针头置于不同组织时，压电传感器在一秒内反馈的压力衰减率差异很大，在肌肉中为2.78%，在皮下为17.28%，在静脉中为54.71%。微团注脉冲注射法和压电传感器密封预充液法在提高放射性药物自动团注注射安全性方面具有应用潜力。
