瑞典哥德堡原发性预防试验中高血压治疗的效果
Effect of treatment of hypertension in the primary preventive trial, Göteborg, Sweden.
作者信息
Wilhelmsen L, Berglund G, Sannerstedt R, Hansson L, Andersson O, Sievertsson R, Wikstrand J
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):261S-265S. doi: 10.1111/j.1365-2125.1979.tb04699.x.
1 A treatment group comprising 635 hypertensive men (casual SBP greater than 175 or DBP greater than 115 twice) was compared with a reference group (n = 391 men; casual SBP greater than 175 or DBP greater than 115 only at screening). All men belonged to the same population sample of 7,455 men aged 47-54 yr. 2 The two groups did not differ with respect to age, smoking habits or cholesterol values, but screening BPs were higher in the treatment group. 3 During 4.3 years' follow-up there was a significantly lower total death rate in the treatment group compared with reference group. 4 There was also a strong tendency towards lower incidence of non-fatal myocardial infarction (P = 0.06). The pooled incidence of non-fatal myocardial infarction and fatal CHD was lower in the treatment group than in the reference group (P less than 0.03).
- 将由635名高血压男性组成的治疗组（偶测收缩压大于175或舒张压大于115，两次测量结果如此）与一个参照组（n = 391名男性；仅在筛查时偶测收缩压大于175或舒张压大于115）进行比较。所有男性均来自年龄在47 - 54岁的7455名男性的同一人群样本。2. 两组在年龄、吸烟习惯或胆固醇值方面无差异，但治疗组的筛查血压较高。3. 在4.3年的随访期间，治疗组的总死亡率显著低于参照组。4. 非致命性心肌梗死的发生率也有明显降低的趋势（P = 0.06）。治疗组非致命性心肌梗死和致命性冠心病的合并发生率低于参照组（P小于0.03）。
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