Lindblad U, Råstam L, Ranstam J
Department of Community Health Sciences, University of Lund, Malmö, Sweden.
Eur Heart J. 1993 Mar;14(3):291-6. doi: 10.1093/eurheartj/14.3.291.
The Skaraborg Hypertension Project was undertaken in 1977-1981, and 1428 male and 1812 female hypertensives aged 40-69 years were involved at hypertension out-patient clinics in primary health care. Their long-term risk of acute myocardial infarction during a follow-up of 8.3 years was compared to that of age- and sex-matched controls drawn from the census register at the beginning of surveillance and to normotensive untreated controls identified in a population survey in 1977. Relative risks (with a 95% confidence interval) for acute myocardial infarction morbidity compared to the population was 0.99 (0.78, 1.25) in men and 1.36 (0.95, 1.94) in women. Corresponding figures for acute myocardial infarction mortality were 0.97 (0.68, 1.38) and 1.15 (0.67, 1.99). With normotensive controls used as reference and adjusting for smoking habits and body mass index, the relative risks for acute myocardial infarction morbidity were 1.48 (1.12, 1.98) in men and 2.34 (1.43, 3.85) in women, and for acute myocardial infarction mortality 1.66 (1.07, 2.57) and 1.71 (0.84, 3.48), respectively. Treated hypertension is a weak risk factor for acute myocardial infarction in unselected hypertensive patients.
斯卡罗堡高血压项目于1977年至1981年开展，1428名年龄在40至69岁之间的男性高血压患者和1812名女性高血压患者参与了初级卫生保健中的高血压门诊。在8.3年的随访期间，将他们发生急性心肌梗死的长期风险与监测开始时从人口普查登记册中抽取的年龄和性别匹配的对照组以及1977年一项人群调查中确定的未经治疗的血压正常对照组进行了比较。与总体人群相比，男性急性心肌梗死发病率的相对风险（95%置信区间）为0.99（0.78，1.25），女性为1.36（0.95，1.94）。急性心肌梗死死亡率的相应数字分别为0.97（0.68，1.38）和1.15（0.67，1.99）。以血压正常的对照组为参照，并对吸烟习惯和体重指数进行调整后，男性急性心肌梗死发病率的相对风险为1.48（1.12，1.98），女性为2.34（1.43，3.85）；急性心肌梗死死亡率的相对风险分别为1.66（1.07，2.57）和1.71（0.84，3.48）。在未经挑选的高血压患者中，治疗后的高血压是急性心肌梗死的一个较弱风险因素。
