Krause U, Faisst G, Cordes U, Beyer J
Horm Metab Res. 1979 Apr;11(4):261-5. doi: 10.1055/s-0028-1092719.
In 10 insulin dependent maturity onset diabetics we found elevated basal C-Peptide levels (4.78 +/- 0.5 ng/ml. Normal range 1.1--3.6 ng/ml), which could be suppressed by insulin injection to the same extent as in sulfonylurea treated diabetics could be demonstrated. C-Peptide immunoreactivity in these patients therefore seems to be newly secreted rather than accumulated material. Since adrenalectomized patients could be suppressed in the same way, it is likely, that catecholamines are not the major factor in the mechanism of suppression. Therefore only decrease of bloodsugar levels seems to be accountable for the decrease of C-Petide levels. High C-Petide levels in insulin dependent maturity onset diabetics which cannot be stimulated but suppressed may be explained by a loss of glucoreceptor molecules.
在10例胰岛素依赖型成年发病型糖尿病患者中，我们发现其基础C肽水平升高（4.78±0.5纳克/毫升，正常范围为1.1 - 3.6纳克/毫升），并且胰岛素注射可将其抑制，抑制程度与磺脲类药物治疗的糖尿病患者相同。因此，这些患者体内的C肽免疫反应性似乎是新分泌的，而非积累的物质。由于肾上腺切除的患者也能以同样的方式被抑制，所以儿茶酚胺不太可能是抑制机制中的主要因素。因此，似乎只有血糖水平的降低可解释C肽水平的下降。胰岛素依赖型成年发病型糖尿病患者中C肽水平高，且无法被刺激却能被抑制，这可能是由于葡萄糖受体分子缺失所致。
